Dynamic contrast-enhanced MRI of oral squamous cell carcinoma

A preliminary study of the correlations between quantitative parameters and the clinical stage

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To probe the utility of dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing the clinical characteristics of oral squamous cell carcinoma. Methods: A total of 85 tumours were included. We applied the Tofts and Kermode model for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (K trans ), the fractional volume of EES per unit volume of tissue (v e ) and the fractional volume of plasma (v p ). We evaluated the correlations between these parameters and the clinical stages. Results: The T stage showed a negative correlation with the K trans (r = -0.2272; p = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with K trans (r = -0.1948; p = 0.0404), and there were significant differences between N1 and N2+3 (0.119 ± 0.027 vs 0.096 ± 0.023 min min -2 ; p = 0.0198) and between N0 and N2+3 (0.114 ± 0.29 vs 0.096 ± 0.023 min min -2 ; p = 0.0288). Conclusion: A decrease in the K trans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the K trans at the primary site suggested the high possibility of an advanced N stage.

Original languageEnglish
Article number20140814
JournalBritish Journal of Radiology
Volume88
Issue number1050
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Extracellular Space
Squamous Cell Carcinoma
Plasma Volume
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{7112a4f1674145798266d87268d4ebbe,
title = "Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: A preliminary study of the correlations between quantitative parameters and the clinical stage",
abstract = "Objective: To probe the utility of dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing the clinical characteristics of oral squamous cell carcinoma. Methods: A total of 85 tumours were included. We applied the Tofts and Kermode model for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (K trans ), the fractional volume of EES per unit volume of tissue (v e ) and the fractional volume of plasma (v p ). We evaluated the correlations between these parameters and the clinical stages. Results: The T stage showed a negative correlation with the K trans (r = -0.2272; p = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with K trans (r = -0.1948; p = 0.0404), and there were significant differences between N1 and N2+3 (0.119 ± 0.027 vs 0.096 ± 0.023 min min -2 ; p = 0.0198) and between N0 and N2+3 (0.114 ± 0.29 vs 0.096 ± 0.023 min min -2 ; p = 0.0288). Conclusion: A decrease in the K trans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the K trans at the primary site suggested the high possibility of an advanced N stage.",
author = "Toru Chikui and Erina Kitamoto and Yukiko Kami and Shintarou Kawano and K. Kobayashi and Takeshi Kamitani and M. Obara and Kazunori Yoshiura",
year = "2015",
month = "6",
day = "1",
doi = "10.1259/bjr.20140814",
language = "English",
volume = "88",
journal = "British Journal of Radiology",
issn = "0007-1285",
publisher = "British Institute of Radiology",
number = "1050",

}

TY - JOUR

T1 - Dynamic contrast-enhanced MRI of oral squamous cell carcinoma

T2 - A preliminary study of the correlations between quantitative parameters and the clinical stage

AU - Chikui, Toru

AU - Kitamoto, Erina

AU - Kami, Yukiko

AU - Kawano, Shintarou

AU - Kobayashi, K.

AU - Kamitani, Takeshi

AU - Obara, M.

AU - Yoshiura, Kazunori

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective: To probe the utility of dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing the clinical characteristics of oral squamous cell carcinoma. Methods: A total of 85 tumours were included. We applied the Tofts and Kermode model for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (K trans ), the fractional volume of EES per unit volume of tissue (v e ) and the fractional volume of plasma (v p ). We evaluated the correlations between these parameters and the clinical stages. Results: The T stage showed a negative correlation with the K trans (r = -0.2272; p = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with K trans (r = -0.1948; p = 0.0404), and there were significant differences between N1 and N2+3 (0.119 ± 0.027 vs 0.096 ± 0.023 min min -2 ; p = 0.0198) and between N0 and N2+3 (0.114 ± 0.29 vs 0.096 ± 0.023 min min -2 ; p = 0.0288). Conclusion: A decrease in the K trans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the K trans at the primary site suggested the high possibility of an advanced N stage.

AB - Objective: To probe the utility of dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing the clinical characteristics of oral squamous cell carcinoma. Methods: A total of 85 tumours were included. We applied the Tofts and Kermode model for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (K trans ), the fractional volume of EES per unit volume of tissue (v e ) and the fractional volume of plasma (v p ). We evaluated the correlations between these parameters and the clinical stages. Results: The T stage showed a negative correlation with the K trans (r = -0.2272; p = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with K trans (r = -0.1948; p = 0.0404), and there were significant differences between N1 and N2+3 (0.119 ± 0.027 vs 0.096 ± 0.023 min min -2 ; p = 0.0198) and between N0 and N2+3 (0.114 ± 0.29 vs 0.096 ± 0.023 min min -2 ; p = 0.0288). Conclusion: A decrease in the K trans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the K trans at the primary site suggested the high possibility of an advanced N stage.

UR - http://www.scopus.com/inward/record.url?scp=84930395257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930395257&partnerID=8YFLogxK

U2 - 10.1259/bjr.20140814

DO - 10.1259/bjr.20140814

M3 - Article

VL - 88

JO - British Journal of Radiology

JF - British Journal of Radiology

SN - 0007-1285

IS - 1050

M1 - 20140814

ER -