Dynamic interfacial properties of polyethylene glycol-modified ferritin at the solid/liquid interface

Yoshikazu Kumashiro, Yasuhiro Ikezoe, Kaoru Tamada, Masahiko Hara

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Poly(ethylene glycol)-modified ferritins (PEG-ferritins) with various molecular weights were synthesized by the grafting method, and their dynamic interfacial properties at the solid/liquid interface were investigated. The number of PEG grafted to ferritins was controlled by the amount of 1,1′-carbonyldiimidazole-modified PEG adding to the reaction solution. The adsorption kinetics and energy dissipation of PEG-ferritins onto bare Si substrate and amino-modified Si substrate were investigated with a quartz crystal microbalance (QCM) in 10 mM bis-Tris/HCl buffer (pH 5.8), while their morphologies were characterized by scanning electron microscopy (SEM). The adsorption dynamics of PEG-ferritins onto amino-modified Si substrate were quite different from those of unmodified ferritin, which can be reasonably interpreted by the desorption capability of PEG-ferritins on the surface attributed to amphiphilicity and the high-chain mobility of PEG chains.

Original languageEnglish
Pages (from-to)8291-8297
Number of pages7
JournalJournal of Physical Chemistry B
Volume112
Issue number28
DOIs
Publication statusPublished - Jul 17 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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