Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection

Chihiro Motozono, Philip Mwimanzi, Takamasa Ueno

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Untreated human immunodeficiency virus (HIV) infections usually lead to death from AIDS, although the rate of the disease progression varies widely among individuals. The cytotoxic T lymphocyte (CTL) response, which is restricted by highly polymorphic MHC class I alleles, plays a central role in controlling HIV replication. It is now recognized that the antiviral efficacy of CTLs at the single cell level is dependent on their antigen specificity and is important in determining the quality of host response to viruses so that the individual will remain asymptomatic. However, because of the extreme mutational plasticity of HIV, HIV-specific CTL responses are continuously and dynamically changing. In order to rationally design an effective vaccine, the questions as to what constitutes an effective antiviral CTL response and what characterizes a potent antigenic peptide to induce such responses are becoming highlighted as needing to be answered.

Original languageEnglish
Pages (from-to)514-519
Number of pages6
JournalProtein and Cell
Volume1
Issue number6
DOIs
Publication statusPublished - Jun 2010

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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