Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development

Tsuyoshi Hirashima, Yoh Iwasa, Yoshihiro Morishita

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In the early kidney development, a simple epithelial tube called ureteric bud is derived from the intermediate mesoderm and undergoes a complex process of growth and terminal bifid branching. The branching of the ureteric bud is achieved by different cellular behaviors including cell proliferation and chemotaxis. In this paper, we examine how the branching morphology depends on different physical or chemical factors by constructing a cell-based model to describe the simple tube branching in the early kidney development. We conclude that a proper balance between growth speed of epithelial sheet due to cell proliferation and cell mobility due to chemotaxis is necessary to realize the development of normal Y-shaped pattern. When cell proliferation is fast compared to chemotaxis, kinked pattern is formed, and when cell proliferation is slow, bloated pattern is formed. These are consistent with experimental observations in different morphological anomalies of mutants. We show that the different branching patterns are accurately predicted by growth-chemotaxis ratio.

Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalJournal of Theoretical Biology
Volume259
Issue number1
DOIs
Publication statusPublished - Jul 7 2009

Fingerprint

Morphogenesis
Cell proliferation
Kidney
Chemotaxis
Dynamic Modeling
Cell Proliferation
morphogenesis
chemotaxis
Branching
branching
buds
kidneys
cell proliferation
Growth
Tube
Mesoderm
Cell
Mutant
Anomaly
cells

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Modelling and Simulation
  • Statistics and Probability
  • Applied Mathematics

Cite this

Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development. / Hirashima, Tsuyoshi; Iwasa, Yoh; Morishita, Yoshihiro.

In: Journal of Theoretical Biology, Vol. 259, No. 1, 07.07.2009, p. 58-66.

Research output: Contribution to journalArticle

Hirashima, Tsuyoshi ; Iwasa, Yoh ; Morishita, Yoshihiro. / Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development. In: Journal of Theoretical Biology. 2009 ; Vol. 259, No. 1. pp. 58-66.
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