Dynamics in the folding of long DNA chain under strong flow

Takuya Saito, Takahiro Sakaue, Daiji Kaneko, Masao Washizu, Hidehiro Oana

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This paper presents the study about the dynamics in the folding of long DNA under strong flow. Di- rect observation of the folding process of the tethered DNA molecule induced by adding a condensing agent is demonstrated using a microfluidic device, and this theoretical interpretation of the process is provided. From the direct observation, it is found that the fold- ing dynamics typically exhibits characteristic three stages: (i) initial rapid compaction, (ii) slowing-down, (iii) sudden speed-up. Such a notable feature pin- points a nonequilibrium flow effect and can be inter- preted by a simple theory, which takes account of the nonuniformity of the tethered chain stretched by flow.

Original languageEnglish
Title of host publication2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, with Symposium on "COE for Education and Research of Micro-Nano Mechatronics"
Pages118-123
Number of pages6
DOIs
Publication statusPublished - Dec 1 2008
Event2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, with Symposium on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "System Cell Engineering by Multi-scale Manipulation" - Nagoya, Japan
Duration: Nov 6 2008Nov 9 2008

Publication series

Name2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008

Other

Other2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, with Symposium on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "System Cell Engineering by Multi-scale Manipulation"
CountryJapan
CityNagoya
Period11/6/0811/9/08

All Science Journal Classification (ASJC) codes

  • Computer Vision and Pattern Recognition
  • Human-Computer Interaction
  • Electrical and Electronic Engineering

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