Dynamics of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotides.

Mariko Aso, Manami Kurita, John Walter Mirc, Toshiyuki Kaneko, Yoshitaka Higuchi, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticlepeer-review

Abstract

We synthesized oligodeoxynucleotide (ODN, 3) containing 2-N-tert-butylaminoxyladenosine (1) and studied EPR spectra of 1 and its duplexes with varied sequences. Duplex formation resulted in a broadening of spectrum and a significant decrease in peak-to-peak height and peak height ratio values. The h(+)/ho values in EPR spectra well correlated with stability of duplex which indicated ODN containing 1 has the potential to monitor DNA structure.

Original languageEnglish
Pages (from-to)151-152
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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