Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma

Kotaro Shide, Hideho Henzan, Koji Nagafuji, Kenichi Aoki, Toshihiro Miyamoto, Kazuya Shimoda, Yukumasa Kazuyama, Koichi Ohshima, Hisashi Gondo, Mine Harada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalJournal of Medical Virology
Volume70
Issue number1
DOIs
Publication statusPublished - May 1 2003

Fingerprint

Pleural Empyema
Human Herpesvirus 4
Lymphoma
Drug Therapy
Neoplasms
Pleurisy
L-Lactate Dehydrogenase
Real-Time Polymerase Chain Reaction
B-Lymphocytes
Radiotherapy
Serum

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Shide, K., Henzan, H., Nagafuji, K., Aoki, K., Miyamoto, T., Shimoda, K., ... Harada, M. (2003). Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma. Journal of Medical Virology, 70(1), 137-140. https://doi.org/10.1002/jmv.10374

Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma. / Shide, Kotaro; Henzan, Hideho; Nagafuji, Koji; Aoki, Kenichi; Miyamoto, Toshihiro; Shimoda, Kazuya; Kazuyama, Yukumasa; Ohshima, Koichi; Gondo, Hisashi; Harada, Mine.

In: Journal of Medical Virology, Vol. 70, No. 1, 01.05.2003, p. 137-140.

Research output: Contribution to journalArticle

Shide, K, Henzan, H, Nagafuji, K, Aoki, K, Miyamoto, T, Shimoda, K, Kazuyama, Y, Ohshima, K, Gondo, H & Harada, M 2003, 'Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma', Journal of Medical Virology, vol. 70, no. 1, pp. 137-140. https://doi.org/10.1002/jmv.10374
Shide, Kotaro ; Henzan, Hideho ; Nagafuji, Koji ; Aoki, Kenichi ; Miyamoto, Toshihiro ; Shimoda, Kazuya ; Kazuyama, Yukumasa ; Ohshima, Koichi ; Gondo, Hisashi ; Harada, Mine. / Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma. In: Journal of Medical Virology. 2003 ; Vol. 70, No. 1. pp. 137-140.
@article{2c53f3550b604caead4cf0a73ff2adab,
title = "Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma",
abstract = "We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.",
author = "Kotaro Shide and Hideho Henzan and Koji Nagafuji and Kenichi Aoki and Toshihiro Miyamoto and Kazuya Shimoda and Yukumasa Kazuyama and Koichi Ohshima and Hisashi Gondo and Mine Harada",
year = "2003",
month = "5",
day = "1",
doi = "10.1002/jmv.10374",
language = "English",
volume = "70",
pages = "137--140",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma

AU - Shide, Kotaro

AU - Henzan, Hideho

AU - Nagafuji, Koji

AU - Aoki, Kenichi

AU - Miyamoto, Toshihiro

AU - Shimoda, Kazuya

AU - Kazuyama, Yukumasa

AU - Ohshima, Koichi

AU - Gondo, Hisashi

AU - Harada, Mine

PY - 2003/5/1

Y1 - 2003/5/1

N2 - We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.

AB - We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=0037401637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037401637&partnerID=8YFLogxK

U2 - 10.1002/jmv.10374

DO - 10.1002/jmv.10374

M3 - Article

VL - 70

SP - 137

EP - 140

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 1

ER -