Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice

Fumiko Takayama, Xinwen Zhang, Yoshinori Hayashi, Zhou Wu, Hiroshi Nakanishi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The expression of cathepsin S (CatS), a microglia-specific lysosomal cysteine protease in the brain, is regulated by the intrinsic microglial circadian clock. We herein report that the diurnal variation of evoked synaptic responses of cortical neurons disappeared in cathepsin S-deficient (CatS−/−) mice. The dendritic spine density of the cortical neurons was significantly reduced by incubation with a recombinant CatS. Furthermore, CatS−/− mice exhibited impaired social interaction and social novelty recognition in the three-chamber test. These findings indicate that the circadian clock-regulated secretion of CatS from microglia is involved in the diurnal variation of synaptic responses and dendritic spine density through the proteolytic modification of perisynaptic ECM molecules. Therefore, a dysfunction of the diurnal synaptic responses due to CatS deficiency may lead to social behavior abnormalities.

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume490
Issue number2
DOIs
Publication statusPublished - Aug 19 2017

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice'. Together they form a unique fingerprint.

Cite this