Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice

Fumiko Takayama, Xinwen Zhang, Yoshinori Hayashi, Hiro Take, Hiroshi Nakanishi

Research output: Contribution to journalArticle

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Abstract

The expression of cathepsin S (CatS), a microglia-specific lysosomal cysteine protease in the brain, is regulated by the intrinsic microglial circadian clock. We herein report that the diurnal variation of evoked synaptic responses of cortical neurons disappeared in cathepsin S-deficient (CatS−/−) mice. The dendritic spine density of the cortical neurons was significantly reduced by incubation with a recombinant CatS. Furthermore, CatS−/− mice exhibited impaired social interaction and social novelty recognition in the three-chamber test. These findings indicate that the circadian clock-regulated secretion of CatS from microglia is involved in the diurnal variation of synaptic responses and dendritic spine density through the proteolytic modification of perisynaptic ECM molecules. Therefore, a dysfunction of the diurnal synaptic responses due to CatS deficiency may lead to social behavior abnormalities.

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume490
Issue number2
DOIs
Publication statusPublished - Aug 19 2017

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cathepsin S
Social Behavior
Neurons
Clocks
Cats
Military electronic countermeasures
Cysteine Proteases
Brain
Dendritic Spines
Circadian Clocks
Microglia
Molecules
Interpersonal Relations

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice. / Takayama, Fumiko; Zhang, Xinwen; Hayashi, Yoshinori; Take, Hiro; Nakanishi, Hiroshi.

In: Biochemical and Biophysical Research Communications, Vol. 490, No. 2, 19.08.2017, p. 447-452.

Research output: Contribution to journalArticle

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