Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis

Masanori Honsho, Yuichi Abe, Yukio Fujiki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Physiological significance of plasmalogen homeostasis remains unknown. Results: Elevation of plasmalogens reduced cholesterol synthesis by enhancing degradation of squalene monooxygenase (SQLE), whereas SQLE was stabilized in the absence of plasmalogens. Conclusion: Plasmalogens regulate cholesterol synthesis by modulating the stability of SQLE. Significance: SQLE stability is modulated in response to the cellular level of plasmalogens, in addition to the acute changes of cholesterol level.

Original languageEnglish
Pages (from-to)28822-28833
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number48
DOIs
Publication statusPublished - Nov 27 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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