Early diagnosis and preventive strategy of corticosteroid induced osteonecrosis in systemic autoimmune diseases

Syuichi Koarada, Yukiko Tokuda, Yukihide Ono, Yuri Sadanaga, Satoko Tashiro, Rie Suematsu, Nobuyuki Ono, Akihide Ohta, Yoshifumi Tada

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Osteonecrosis of femoral head (ONF) is one of the serious adverse events in the patients with systemic lupus erythematosus (SLE) associated with corticosteroid therapy. We have reported a multicenter prospective study of prevention of ONF in SLE patients on high doses of corticosteroids using anticoagulant of warfarin. In the diagnosis of ONF, plain radiography and magnetic resonance imaging (MRI) are important. Especially, in early stage of ONF, although the plain radiograph is still normal, evident changes can be seen in MRI. The treatment of ONFremains controversial. Anticoagulants may be useful to prevent ONF. Therefore, early diagnosis and prevention of ONF are critical issues especially in SLE patients. In this chapter, we present the radiological images illustrating osteonecrosis in patients with autoimmune diseases including SLE, and review the strategy to prevent ONF induced by corticosteroids.

Original languageEnglish
Title of host publicationCorticosteroids and Steroid Therapy
Subtitle of host publicationNew Research
PublisherNova Science Publishers, Inc.
Pages79-100
Number of pages22
ISBN (Electronic)9781634823333
ISBN (Print)9781634823081
Publication statusPublished - Apr 1 2015

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Koarada, S., Tokuda, Y., Ono, Y., Sadanaga, Y., Tashiro, S., Suematsu, R., Ono, N., Ohta, A., & Tada, Y. (2015). Early diagnosis and preventive strategy of corticosteroid induced osteonecrosis in systemic autoimmune diseases. In Corticosteroids and Steroid Therapy: New Research (pp. 79-100). Nova Science Publishers, Inc..