Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinalmyocardial relaxation

Kazunori Okada, Taisei Mikami, Sanae Kaga, Hisao Onozuka, Mamiko Inoue, Shinobu Yokoyama, Hisao Nishino, Mutsumi Nishida, Kazuhiko Matsuno, Hiroyuki Iwano, Satoshi Yamada, Hiroyuki Tsutsui

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Abstract

Aims Early diastolic mitral annular velocity (e') obtained by tissue Doppler imaging (TDI) is widely used to evaluate left ventricular (LV) diastolic function based on the assumption that it reflects myocardial relaxation in the long-axis direction. In this study, we aimed to determine whether or not e' truly reflects early diastolic longitudinal myocardial relaxation, and which is the most useful for evaluating LV diastolic function among e' measured at the interventricularseptal annulus (IS-e'), that measured at the lateral annulus (LW-e') or their mean value (M-e'). Methods and results IS-e', LW-e', and M-e' were measured using colour TDI in 15 patients with hypertrophic cardiomyopathy, 13 patients with hypertension, and 19 control subjects. Using two-dimensional speckle-tracking imaging, early diastolic myocardial strain rates (SR E) were measured for the IS (IS-SR E), LW(LW-SR E), and entire LV myocardium (G-SR E). IS-e' was excellently correlated with IS-SR E (r = 0.90, P < 0.001); the correlation was better than that between LW-e' and LW-SR E (r = 0.75, P < 0.001). IS-e' and M-e' were well correlated with G-SR E (r = 0.88, P < 0.001 and r = 0.86, P < 0.001, respectively) and with LV early diastolic flow propagation velocity (FPV) (r = 0.77, P < 0.001 and r = 0.78, P < 0.001, respectively). The correlations of LW-e' to G-SR E (r = 0.80, P < 0.001) and FPV (r = 0.75, P < 0.001) did not reach this level. Conclusion IS-e' well reflected LV longitudinal myocardial relaxation and LV diastolic function, and was found to be more useful in evaluating LV diastolic function than LW-e'.

Original languageEnglish
Pages (from-to)917-923
Number of pages7
JournalEuropean Journal of Echocardiography
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Okada, K., Mikami, T., Kaga, S., Onozuka, H., Inoue, M., Yokoyama, S., Nishino, H., Nishida, M., Matsuno, K., Iwano, H., Yamada, S., & Tsutsui, H. (2011). Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinalmyocardial relaxation. European Journal of Echocardiography, 12(12), 917-923. https://doi.org/10.1093/ejechocard/jer154