Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Masaki Yamamoto; Tsukasa Hori; Naoki Hatakeyama; Keita Igarashi; Natsuko Inazawa; Nobuhiro Suzuki; Norio Takei; Yoichi M. Ito; Kimikazu Matsumoto; Koji Kato; Hiroyuki Tsutsumi; Yasuo Kokai

doi:10.15114/smj.86.45

Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Masaki Yamamoto, Tsukasa Hori, Naoki Hatakeyama, Keita Igarashi, Natsuko Inazawa, Nobuhiro Suzuki, Norio Takei, Yoichi M. Ito, Kimikazu Matsumoto, Koji Kato, Hiroyuki Tsutsumi, Yasuo Kokai

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versus-host disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II-IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower survival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis.

Original language	English
Pages (from-to)	45-51
Number of pages	7
Journal	Sapporo Medical journal
Volume	86
Issue number	1-6
DOIs	https://doi.org/10.15114/smj.86.45
Publication status	Published - Dec 2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.15114/smj.86.45

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title = "Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation",

abstract = "To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versus-host disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II-IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower survival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis.",

author = "Masaki Yamamoto and Tsukasa Hori and Naoki Hatakeyama and Keita Igarashi and Natsuko Inazawa and Nobuhiro Suzuki and Norio Takei and Ito, {Yoichi M.} and Kimikazu Matsumoto and Koji Kato and Hiroyuki Tsutsumi and Yasuo Kokai",

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doi = "10.15114/smj.86.45",

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T1 - Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation

AU - Yamamoto, Masaki

AU - Hori, Tsukasa

AU - Hatakeyama, Naoki

AU - Igarashi, Keita

AU - Inazawa, Natsuko

AU - Suzuki, Nobuhiro

AU - Takei, Norio

AU - Ito, Yoichi M.

AU - Matsumoto, Kimikazu

AU - Kato, Koji

AU - Tsutsumi, Hiroyuki

AU - Kokai, Yasuo

PY - 2017/12

Y1 - 2017/12

N2 - To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versus-host disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II-IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower survival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis.

AB - To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versus-host disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II-IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower survival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis.

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JF - Sapporo Medical Journal

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Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Abstract

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