Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Masaki Yamamoto, Tsukasa Hori, Naoki Hatakeyama, Keita Igarashi, Natsuko Inazawa, Nobuhiro Suzuki, Norio Takei, Yoichi M. Ito, Kimikazu Matsumoto, Koji Kato, Hiroyuki Tsutsumi, Yasuo Kokai

Research output: Contribution to journalArticle

Abstract

To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versus-host disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II-IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower survival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalSapporo Medical journal
Volume86
Issue number1-6
DOIs
Publication statusPublished - Dec 2017
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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