Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Hirokatsu Saito, Kenshiro Hara, Takashi Tominaga, Kinichi Nakashima, Kentaro Tanemura

Research output: Contribution to journalArticle

Abstract

Permethrin, a pyrethroid chemical, is widely used as a pesticide because of its rapid insecticidal activity. Although permethrin is considered to exert very low toxicity in mammals, the effects of early, low-level, chronic exposure on the adult central nervous system are unclear. In this study, we investigated the effects of low-level, chronic permethrin exposure in early life on the brain functions of adult mice, using environmentally relevant concentrations. We exposed mice to the acceptable daily intake level of permethrin (0.3 ppm) in drinking water during the prenatal and postnatal periods. We then examined the effects on the central nervous system in adult male offspring. In the permethrin group, we detected behavior that displayed incomplete adaptation to a novel environment, as well as an impairment in learning and memory. In addition, immunohistochemical analysis revealed an increase in doublecortin- (an immature neuron marker) positive cells in the hippocampal dentate gyrus in the permethrin exposure group compared with the control group. Additionally, in the permethrin exposure group there was a decrease in astrocyte number in the hilus of the dentate gyrus, and remaining astrocytes were often irregularly shaped. These results suggest that exposure to permethrin at low levels in early life affects the formation of the neural circuit base and behavior after maturation. Therefore, in the central nervous system of male mice, low-level, chronic permethrin exposure during the prenatal and postnatal periods has effects that were not expected based on the known effects of permethrin exposure in mature animals.

Original languageEnglish
JournalJournal of Applied Toxicology
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Permethrin
Neuroglia
Learning
Data storage equipment
Population
Neurology
Central Nervous System
Dentate Gyrus
Astrocytes
No-Observed-Adverse-Effect Level
Pyrethrins
Parahippocampal Gyrus
Mammals
Pesticides
Drinking Water
Neurons
Toxicity
Brain
Animals
Cells

All Science Journal Classification (ASJC) codes

  • Toxicology

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Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice. / Saito, Hirokatsu; Hara, Kenshiro; Tominaga, Takashi; Nakashima, Kinichi; Tanemura, Kentaro.

In: Journal of Applied Toxicology, 01.01.2019.

Research output: Contribution to journalArticle

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