Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus-pituitary-adrenal axis

Yoichi Chida, Nobuyuki Sudo, Junko Sonoda, Tetsuya Hiramoto, Chiharu Kubo

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Rationale: Despite accumulating evidence that psychological stress has a short-lasting detrimental effect on asthma, little is known about the way stress in childhood predisposes to adult asthma. Objectives: Using a communication box, we investigated the long-lasting effect of early psychological and physical stress on adult asthma in mice. Methods: Male BALB/c mice were exposed to either psychological stress or physical stress three times (every other day) during their fourth week of life. The mice were sensitized to ovalbumin at 8 and 10 weeks, and an ovalbumin airway challenge was conducted at the age of 11 weeks. Results: Twenty-four hours after ovalbumin challenge, both psychological and physical stress-exposed mice exhibited a significant acceleration in the number of total mononuclear cells and eosinophils and airway hyperresponsiveness compared with control mice. No differences in serum anti-OVA-specific immunoglobulin E levels were found between stress-exposed and control animals after antigen sensitization. In the psychological stress group, but not in the physical stress group, an elevation of the serum corticosterone levels during ovalbumin challengewas significantly attenuated in comparison with the control group. Moreover, pretreatment with RU-486, a glucocorticoid receptor antagonist, before ovalbumin challenge completely inhibited a psychological stress-induced exacerbation of asthma. However, pretreatment with GR-82334, a neurokinin-1 receptor antagonist, failed to affect physical stress-induced augmentation of airway inflammation. Conclusion: Early psychological and physical stresses aggravated adult asthma via hyporesponsiveness of the hypothalamic-pituitary- adrenal axis during antigen challenge and via a pathway(s) distinct from the hypothalamic-pituitary-adrenal axis or neurokinin-1 receptors.

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume175
Issue number4
DOIs
Publication statusPublished - Feb 15 2007

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Psychological Stress
Hypothalamus
Ovalbumin
Asthma
Neurokinin-1 Receptor Antagonists
Neurokinin-1 Receptors
Antigens
Mifepristone
Glucocorticoid Receptors
Corticosterone
Serum
Eosinophils
Immunoglobulin E
Communication
Inflammation
Control Groups

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus-pituitary-adrenal axis. / Chida, Yoichi; Sudo, Nobuyuki; Sonoda, Junko; Hiramoto, Tetsuya; Kubo, Chiharu.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 175, No. 4, 15.02.2007, p. 316-322.

Research output: Contribution to journalArticle

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