Early-onset sarcoidosis mimicking refractory cutaneous histiocytosis

Shouichi Ohga, Kiyomi Ichino, Kazunori Urabe, Masataka Ishimura, Hidetoshi Takada, Ryuta Nishikomori, Masutaka Furue, Toshiro Hara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 10-year-old female was diagnosed as having early-onset sarcoidosis (EOS) after a prolonged skin disease. A granuloma emerged on the face at age 2 and massive lesions extended to the rest of the body. Repeated biopsies indicated histiocytic proliferation. At age 7, fever, disseminated macular eruptions, and multinucleated giant cells in the bone marrow prompted vinblastine and prednisolone therapy. Five months after stopping therapy, hypercalcemic crisis occurred along with fever, cytopenias, and interferon-γ-nemia indicating a macrophage activation syndrome. A biopsy of nodules confirmed the diagnosis of sarcoidosis. The atypical EOS should be differentiated from histiocytosis.

Original languageEnglish
Pages (from-to)723-726
Number of pages4
JournalPediatric Blood and Cancer
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 2008

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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