Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer

Y. Maehara; K. Sugimachi; M. Akagi; T. Kakegawa; H. Shimazu; M. Tomita

doi:10.1038/bjc.1992.84

Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer

Y. Maehara, K. Sugimachi, M. Akagi, T. Kakegawa, H. Shimazu, M. Tomita

Surgery

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Abstract

We studied the effect of early postoperative chemotherapy, including 5-fluorouracil (5-FU) for 5 days for patients with gastric cancer following noncurative resection. The study was prospectively randomised and controlled, and 162 (87. 1%) of 186 were eligible candidates for statistical assessment. Patients randomised to group A received therapy that is used widely to treat patients with gastric cancer in Japan; mitomycin C (MMC). OK-432. UFT and PSK. Patients randomised to group B received the same drugs given to group A plus 5-FU bolus injections for 5 days, beginning on postoperative day 2. There were no differences in prognostic factors and doses of the drugs prescribed, except for 5-FU. There was no difference in the toxicity rate between the groups. Generalised Wilcoxon test revealed a P value of 0. 169. and the 50% survival rate improved 1. 4-fold in patients with gastric cancer treated with early postoperative chemotherapy of MMC. OK-432 plus 5-FU injection.

Original language	English
Pages (from-to)	413-416
Number of pages	4
Journal	British journal of cancer
Volume	65
Issue number	3
DOIs	https://doi.org/10.1038/bjc.1992.84
Publication status	Published - Mar 1992

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer",

abstract = "We studied the effect of early postoperative chemotherapy, including 5-fluorouracil (5-FU) for 5 days for patients with gastric cancer following noncurative resection. The study was prospectively randomised and controlled, and 162 (87. 1%) of 186 were eligible candidates for statistical assessment. Patients randomised to group A received therapy that is used widely to treat patients with gastric cancer in Japan; mitomycin C (MMC). OK-432. UFT and PSK. Patients randomised to group B received the same drugs given to group A plus 5-FU bolus injections for 5 days, beginning on postoperative day 2. There were no differences in prognostic factors and doses of the drugs prescribed, except for 5-FU. There was no difference in the toxicity rate between the groups. Generalised Wilcoxon test revealed a P value of 0. 169. and the 50% survival rate improved 1. 4-fold in patients with gastric cancer treated with early postoperative chemotherapy of MMC. OK-432 plus 5-FU injection.",

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AU - Maehara, Y.

AU - Sugimachi, K.

AU - Akagi, M.

AU - Kakegawa, T.

AU - Shimazu, H.

AU - Tomita, M.

PY - 1992/3

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