Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer

Y. Maehara, K. Sugimachi, M. Akagi, T. Kakegawa, H. Shimazu, M. Tomita

Research output: Contribution to journalArticle

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Abstract

We studied the effect of early postoperative chemotherapy, including 5-fluorouracil (5-FU) for 5 days for patients with gastric cancer following noncurative resection. The study was prospectively randomised and controlled, and 162 (87. 1%) of 186 were eligible candidates for statistical assessment. Patients randomised to group A received therapy that is used widely to treat patients with gastric cancer in Japan; mitomycin C (MMC). OK-432. UFT and PSK. Patients randomised to group B received the same drugs given to group A plus 5-FU bolus injections for 5 days, beginning on postoperative day 2. There were no differences in prognostic factors and doses of the drugs prescribed, except for 5-FU. There was no difference in the toxicity rate between the groups. Generalised Wilcoxon test revealed a P value of 0. 169. and the 50% survival rate improved 1. 4-fold in patients with gastric cancer treated with early postoperative chemotherapy of MMC. OK-432 plus 5-FU injection.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalBritish journal of cancer
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 1992

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Stomach Neoplasms
Fluorouracil
Drug Therapy
Picibanil
Mitomycin
Injections
Pharmaceutical Preparations
Japan
Survival Rate
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer. / Maehara, Y.; Sugimachi, K.; Akagi, M.; Kakegawa, T.; Shimazu, H.; Tomita, M.

In: British journal of cancer, Vol. 65, No. 3, 03.1992, p. 413-416.

Research output: Contribution to journalArticle

Maehara, Y, Sugimachi, K, Akagi, M, Kakegawa, T, Shimazu, H & Tomita, M 1992, 'Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer', British journal of cancer, vol. 65, no. 3, pp. 413-416. https://doi.org/10.1038/bjc.1992.84
Maehara, Y. ; Sugimachi, K. ; Akagi, M. ; Kakegawa, T. ; Shimazu, H. ; Tomita, M. / Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer. In: British journal of cancer. 1992 ; Vol. 65, No. 3. pp. 413-416.
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