Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

Toshihiro Mlyamoto, Hsashi Gondo, Yasushi Mlyoshi, Hrokazu Snigematsu, Toshio Mlnematsu, Katsuto Takenaka, Kazuki Tanimoio, Takahiko Horiucm, Yoshinobu Asano, Shoichi Inaba, Yoichi Minamishima, Yosniyuki Niho

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41 Citations (Scopus)

Abstract

A patient with non-Hodgkin's lymphoma who received a CD34-selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus-associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft and a persistent decrease in CD4+ lymphocytes following PBSCT may have predisposed this patient to such viral infections. Infusion of cryopreserved autologous PBSC (containing mature T cells) was effective for adenovirus-associated HC. Immunosuppression and resultant vital infections may affect patients receiving CD34-selected autologous transplantation.

Original languageEnglish
Pages (from-to)348-350
Number of pages3
JournalBritish Journal of Haematology
Volume100
Issue number2
DOIs
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Hematology

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