Echocardiographic predictors of poor prognosis in congenital diaphragmatic hernia

Masaya Yamoto, Noboru Inamura, Keita Terui, Kouji Nagata, Yutaka Kanamori, Masahiro Hayakawa, Yuko Tazuke, Akiko Yokoi, Hajime Takayasu, Hiroomi Okuyama, Koji Fukumoto, Naoto Urushihara, Tomoaki Taguchi, Noriaki Usui

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7 Citations (Scopus)

Abstract

Background/purpose The purpose of this study was to investigate echocardiographic parameters in relation to the outcomes of isolated left-sided congenital diaphragmatic hernia (CDH). Methods This multicenter, retrospective, observational study was conducted among patients with CDH born between 2006 and 2010. Patients in this study did not have severe cardiac malformations or chromosomal aberrations. Patients with incomplete echocardiographic examinations were excluded. In total, 84 patients with left-sided isolated CDH were included in this study. The prognostic parameters were obtained from postnatal echocardiographic images within 24 h after birth. Results Eight patients died before 90 days of birth. Univariate analysis showed that the presence of continuous right to left shunt at the ductus, left pulmonary artery diameter of < 2.7 mm, right pulmonary artery diameter of < 3.3 mm, and left ventricular diastolic diameter of < 10.8 mm, were the predictors of poor prognosis. Multivariate logistic regression analysis showed that right pulmonary artery diameter of < 3.3 mm (adjusted OR 10.28, 95% C.I.: 1.15–249.19) and left ventricular diastolic diameter of < 10.8 mm (adjusted OR 7.86, 95% C.I.: 1.01–82.82) were predictors of poor prognosis. Conclusions This study revealed that the predictors of poor prognosis associated with CDH include smaller right pulmonary artery and left ventricular diastolic diameters. Retrospective Study-Level II.

Original languageEnglish
Pages (from-to)1926-1930
Number of pages5
JournalJournal of Pediatric Surgery
Volume51
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

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Pulmonary Artery
Retrospective Studies
Parturition
Chromosome Aberrations
Observational Studies
Logistic Models
Regression Analysis
Congenital Diaphragmatic Hernias

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Yamoto, M., Inamura, N., Terui, K., Nagata, K., Kanamori, Y., Hayakawa, M., ... Usui, N. (2016). Echocardiographic predictors of poor prognosis in congenital diaphragmatic hernia. Journal of Pediatric Surgery, 51(12), 1926-1930. https://doi.org/10.1016/j.jpedsurg.2016.09.014

Echocardiographic predictors of poor prognosis in congenital diaphragmatic hernia. / Yamoto, Masaya; Inamura, Noboru; Terui, Keita; Nagata, Kouji; Kanamori, Yutaka; Hayakawa, Masahiro; Tazuke, Yuko; Yokoi, Akiko; Takayasu, Hajime; Okuyama, Hiroomi; Fukumoto, Koji; Urushihara, Naoto; Taguchi, Tomoaki; Usui, Noriaki.

In: Journal of Pediatric Surgery, Vol. 51, No. 12, 01.12.2016, p. 1926-1930.

Research output: Contribution to journalArticle

Yamoto, M, Inamura, N, Terui, K, Nagata, K, Kanamori, Y, Hayakawa, M, Tazuke, Y, Yokoi, A, Takayasu, H, Okuyama, H, Fukumoto, K, Urushihara, N, Taguchi, T & Usui, N 2016, 'Echocardiographic predictors of poor prognosis in congenital diaphragmatic hernia', Journal of Pediatric Surgery, vol. 51, no. 12, pp. 1926-1930. https://doi.org/10.1016/j.jpedsurg.2016.09.014
Yamoto, Masaya ; Inamura, Noboru ; Terui, Keita ; Nagata, Kouji ; Kanamori, Yutaka ; Hayakawa, Masahiro ; Tazuke, Yuko ; Yokoi, Akiko ; Takayasu, Hajime ; Okuyama, Hiroomi ; Fukumoto, Koji ; Urushihara, Naoto ; Taguchi, Tomoaki ; Usui, Noriaki. / Echocardiographic predictors of poor prognosis in congenital diaphragmatic hernia. In: Journal of Pediatric Surgery. 2016 ; Vol. 51, No. 12. pp. 1926-1930.
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abstract = "Background/purpose The purpose of this study was to investigate echocardiographic parameters in relation to the outcomes of isolated left-sided congenital diaphragmatic hernia (CDH). Methods This multicenter, retrospective, observational study was conducted among patients with CDH born between 2006 and 2010. Patients in this study did not have severe cardiac malformations or chromosomal aberrations. Patients with incomplete echocardiographic examinations were excluded. In total, 84 patients with left-sided isolated CDH were included in this study. The prognostic parameters were obtained from postnatal echocardiographic images within 24 h after birth. Results Eight patients died before 90 days of birth. Univariate analysis showed that the presence of continuous right to left shunt at the ductus, left pulmonary artery diameter of < 2.7 mm, right pulmonary artery diameter of < 3.3 mm, and left ventricular diastolic diameter of < 10.8 mm, were the predictors of poor prognosis. Multivariate logistic regression analysis showed that right pulmonary artery diameter of < 3.3 mm (adjusted OR 10.28, 95{\%} C.I.: 1.15–249.19) and left ventricular diastolic diameter of < 10.8 mm (adjusted OR 7.86, 95{\%} C.I.: 1.01–82.82) were predictors of poor prognosis. Conclusions This study revealed that the predictors of poor prognosis associated with CDH include smaller right pulmonary artery and left ventricular diastolic diameters. Retrospective Study-Level II.",
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AU - Inamura, Noboru

AU - Terui, Keita

AU - Nagata, Kouji

AU - Kanamori, Yutaka

AU - Hayakawa, Masahiro

AU - Tazuke, Yuko

AU - Yokoi, Akiko

AU - Takayasu, Hajime

AU - Okuyama, Hiroomi

AU - Fukumoto, Koji

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AU - Taguchi, Tomoaki

AU - Usui, Noriaki

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