Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance

Yasuhiro Tada, Akira Yokomizo, Masaki Shiota, Yoohyun Song, Eiji Kashiwagi, Kentaro Kuroiwa, Yoshinao Oda, Seiji Naito

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6 Citations (Scopus)

Abstract

The development of resistance to cisplatin during treatment of testicular cancer constitutes a major obstacle to the cure of testicular cancer. To resolve its mechanism will provide useful information for making clinical decisions. We found 4 and 15 gene expressions were, respectively, up-regulated and down-regulated in cisplatin-resistant testicular cancer NEC-8/DDP cells compared with their parental NEC-8 cells (about 2.5-fold) using cDNA microarray analysis. After screening, we selected the ENTPD6 among these 19 genes. ENTPD6 was less expressed in cancerous region compared with that in non-cancerous lesion. In addition, ENTPD6 expression in seminoma was higher than that in other testicular tumors. ENTPD6 expression was involved in cellular sensitivity to cisplatin through an interaction with E-cadherin. ENTFD6 is a promising molecular biomarker of cisplatin resistance in testicular cancer, and also a novel therapeutical target modulating cisplatin resistance in testicular cancer.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalOncology reports
Volume26
Issue number1
DOIs
Publication statusPublished - Jul 1 2011

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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