TY - JOUR
T1 - EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy
T2 - A retrospective study and literature review
AU - Tashiro, Kenshi
AU - Ogata, Katsuya
AU - Goto, Yoshinobu
AU - Taniwaki, Takayuki
AU - Okayama, Akira
AU - Kira, Jun ichi
AU - Tobimatsu, Shozo
PY - 2006/10
Y1 - 2006/10
N2 - Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0%), but only 2 PSP patients (14.3%) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0%) and 5 PSP patients (35.7%) (p = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages.
AB - Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0%), but only 2 PSP patients (14.3%) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0%) and 5 PSP patients (35.7%) (p = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages.
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U2 - 10.1016/j.clinph.2006.06.710
DO - 10.1016/j.clinph.2006.06.710
M3 - Article
C2 - 16920021
AN - SCOPUS:33748306341
SN - 1388-2457
VL - 117
SP - 2236
EP - 2242
JO - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
JF - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
IS - 10
ER -