EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy: A retrospective study and literature review

Kenshi Tashiro, Katsuya Ogata, Yoshinobu Goto, Takayuki Taniwaki, Akira Okayama, Jun-Ichi Kira, Shozo Tobimatsu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0%), but only 2 PSP patients (14.3%) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0%) and 5 PSP patients (35.7%) (p = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages.

Original languageEnglish
Pages (from-to)2236-2242
Number of pages7
JournalClinical Neurophysiology
Volume117
Issue number10
DOIs
Publication statusPublished - Oct 1 2006

Fingerprint

Progressive Supranuclear Palsy
Electroencephalography
Retrospective Studies
Neuroimaging
Atrophy

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy : A retrospective study and literature review. / Tashiro, Kenshi; Ogata, Katsuya; Goto, Yoshinobu; Taniwaki, Takayuki; Okayama, Akira; Kira, Jun-Ichi; Tobimatsu, Shozo.

In: Clinical Neurophysiology, Vol. 117, No. 10, 01.10.2006, p. 2236-2242.

Research output: Contribution to journalArticle

Tashiro, Kenshi ; Ogata, Katsuya ; Goto, Yoshinobu ; Taniwaki, Takayuki ; Okayama, Akira ; Kira, Jun-Ichi ; Tobimatsu, Shozo. / EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy : A retrospective study and literature review. In: Clinical Neurophysiology. 2006 ; Vol. 117, No. 10. pp. 2236-2242.
@article{8f64bc0d675a4c24808e966410308c86,
title = "EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy: A retrospective study and literature review",
abstract = "Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0{\%}), but only 2 PSP patients (14.3{\%}) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0{\%}) and 5 PSP patients (35.7{\%}) (p = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages.",
author = "Kenshi Tashiro and Katsuya Ogata and Yoshinobu Goto and Takayuki Taniwaki and Akira Okayama and Jun-Ichi Kira and Shozo Tobimatsu",
year = "2006",
month = "10",
day = "1",
doi = "10.1016/j.clinph.2006.06.710",
language = "English",
volume = "117",
pages = "2236--2242",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "10",

}

TY - JOUR

T1 - EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy

T2 - A retrospective study and literature review

AU - Tashiro, Kenshi

AU - Ogata, Katsuya

AU - Goto, Yoshinobu

AU - Taniwaki, Takayuki

AU - Okayama, Akira

AU - Kira, Jun-Ichi

AU - Tobimatsu, Shozo

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0%), but only 2 PSP patients (14.3%) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0%) and 5 PSP patients (35.7%) (p = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages.

AB - Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0%), but only 2 PSP patients (14.3%) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0%) and 5 PSP patients (35.7%) (p = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages.

UR - http://www.scopus.com/inward/record.url?scp=33748306341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748306341&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2006.06.710

DO - 10.1016/j.clinph.2006.06.710

M3 - Article

C2 - 16920021

AN - SCOPUS:33748306341

VL - 117

SP - 2236

EP - 2242

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 10

ER -