Effect of a traditional chinese medicine, bu-zhong-yi-qi-tang (japanese name: Hochu-ekki-to) on the protection against listeria monocytogenes infection in mice

Xiao Yan Li, Hiroaki Takimoto, Shin Ich Miura, Yasunobu Yoshikai, Goro Matsuzaki, Kikuo Nomoto

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    ABSTRCTS Effects of Bu-Zhong-Yi-Qi-Tang (Japanese name : Hochu-ekki-to) on the resistance against Listeria monocytogenes were observed in ICR mice orally administered this medicine daily for 10 days. Survival rates were increased by the pretreatment in mice inoculated i.v. with bacteria 1 day after the last administration and in mice inoculated i.p. 4 days after the last administration. After an i.v. inoculation of L. monocytogenes, the numbers of bacteria in the spleen and liver increased gradually to kill mice by day 5 in untreated group but the bacterial numbers increased slightly by day 3 and decreased from day 3 to day 8 in Hochu-ekki-to pretreated group. After an i.p. inoculation, the number of bacteria in the peritoneal cavity decreased very rapidly within 6h in Hochu-ekki-to treated group compared to that in untreated group. After the administration, number of polymorphonuclear cells increased in the peripheral blood, peritoneal cavity and spleen. In treated mice, macrophages increased in number in the peritoneal cavity and the spleen but decreased in the peripheral blood. Peritoneal macrophages from treated mice showed an enhanced activity to kill L. monocytogenes in vitro within 60 min after ingestion of bacteria. Hochu-ekki-to may augment the host defense against L. monocytogenes through the activation of macrophage series during an early phase of infection.

    Original languageEnglish
    Pages (from-to)383-402
    Number of pages20
    JournalImmunopharmacology and Immunotoxicology
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 1992

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Toxicology
    • Pharmacology

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