Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats

Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the present study, we aimed to evaluate the effect of aging on the absorption of small peptides in spontaneously hypertensive rats (SHRs). Three kinds of dipeptides, glycyl-sarcosine (Gly-Sar), Trp-His, and captopril (a dipeptidomimetic drug), a Gly-Sar-Sar tripeptide, a Gly-Sar-Sar-Sar tetrapeptide, and a Gly-Sar-Sar-Sar-Sar pentapeptide were administered at doses of 10 mg/kg each to 8- and 40-week-old SHRs. The peptides were all detected in their intact forms in the blood. There was a significantly promoted absorption of di/tripeptides in aged SHRs compared with young SHRs. In contrast, the absorption of tetra/pentapeptides was not affected by aging. PepT1 expression in the mid-jejunum was significantly increased in 40-week-old SHRs compared with 8-week-old SHRs, whereas aging did not alter the expression of claudin-1, a tight junction related protein. Thus, the present results suggest that SHR aging may enhance the absorption of di/tripeptides through the enhanced PepT1 transport route, although oligopeptides may be absorbed in an age-independent manner.

Original languageEnglish
Pages (from-to)5935-5943
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number29
DOIs
Publication statusPublished - Jul 26 2017

Fingerprint

Inbred SHR Rats
Rats
Sarcosine
Aging of materials
peptides
Peptides
rats
tripeptides
tryptophyl-histidine
Claudin-1
Tight Junction Proteins
oligopeptides
Oligopeptides
tight junctions
dipeptides
Dipeptides
Captopril
Jejunum
jejunum
Blood

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. / Hanh, Vu Thi; Shen, Weilin; Tanaka, Mitsuru; Siltari, Aino; Korpela, Riita; Matsui, Toshiro.

In: Journal of Agricultural and Food Chemistry, Vol. 65, No. 29, 26.07.2017, p. 5935-5943.

Research output: Contribution to journalArticle

Hanh, Vu Thi ; Shen, Weilin ; Tanaka, Mitsuru ; Siltari, Aino ; Korpela, Riita ; Matsui, Toshiro. / Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. In: Journal of Agricultural and Food Chemistry. 2017 ; Vol. 65, No. 29. pp. 5935-5943.
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