Effect of allergen sensitization on external root resorption

N. Murata, H. Ioi, M. Ouchi, T. Takao, H. Oida, R. Aijima, Takayoshi Yamaza, M. A. Kido

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In orthodontic tooth movement (OTM), we should be concerned about external root resorption (ERR) as an undesirable iatrogenic problem, but its mechanisms are not fully understood. Since our previous epidemiologic studies found that patients with allergic diseases showed higher rates of ERR during orthodontic treatment, we explored the possible effect of allergic sensitization on ERR. In ovalbumin (OVA)-sensitized Brown-Norway rats, the amounts of ERR and OTM were greater than those in animals subjected to orthodontic force alone. The expression levels of RANKL and pro-inflammatory cytokines were increased in the periodontal tissues of sensitized rats with OTM, compared with control rats. Furthermore, leukotriene B4 (LTB4), a potent lipid mediator of allergic inflammation, and enzymes of the 5-lipoxygenase pathway, the biosynthetic pathway of leukotrienes, were also up-regulated. We found that low doses of aspirin suppressed ERR in allergen-sensitized rats, as well as the expressions of RANKL, pro-inflammatory cytokines, and LTB4. The present findings indicate that allergen sensitization has adverse effects on ERR under OTM, and that aspirin is a potential therapeutic agent for combating ERR.

Original languageEnglish
Pages (from-to)641-647
Number of pages7
JournalJournal of Dental Research
Volume92
Issue number7
DOIs
Publication statusPublished - Jul 1 2013

Fingerprint

Root Resorption
Allergens
Tooth Movement Techniques
Leukotriene B4
Orthodontics
Aspirin
Cytokines
Arachidonate 5-Lipoxygenase
Inflammation Mediators
Leukotrienes
Biosynthetic Pathways
Ovalbumin
Epidemiologic Studies
Lipids
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Murata, N., Ioi, H., Ouchi, M., Takao, T., Oida, H., Aijima, R., ... Kido, M. A. (2013). Effect of allergen sensitization on external root resorption. Journal of Dental Research, 92(7), 641-647. https://doi.org/10.1177/0022034513488787

Effect of allergen sensitization on external root resorption. / Murata, N.; Ioi, H.; Ouchi, M.; Takao, T.; Oida, H.; Aijima, R.; Yamaza, Takayoshi; Kido, M. A.

In: Journal of Dental Research, Vol. 92, No. 7, 01.07.2013, p. 641-647.

Research output: Contribution to journalArticle

Murata, N, Ioi, H, Ouchi, M, Takao, T, Oida, H, Aijima, R, Yamaza, T & Kido, MA 2013, 'Effect of allergen sensitization on external root resorption', Journal of Dental Research, vol. 92, no. 7, pp. 641-647. https://doi.org/10.1177/0022034513488787
Murata N, Ioi H, Ouchi M, Takao T, Oida H, Aijima R et al. Effect of allergen sensitization on external root resorption. Journal of Dental Research. 2013 Jul 1;92(7):641-647. https://doi.org/10.1177/0022034513488787
Murata, N. ; Ioi, H. ; Ouchi, M. ; Takao, T. ; Oida, H. ; Aijima, R. ; Yamaza, Takayoshi ; Kido, M. A. / Effect of allergen sensitization on external root resorption. In: Journal of Dental Research. 2013 ; Vol. 92, No. 7. pp. 641-647.
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