TY - JOUR
T1 - Effect of amount of hydrated water and mobility of hydrated poly(2-methoxyethyl acrylate) on denaturation of adsorbed fibrinogen
AU - Ueda, Tomoya
AU - Murakami, Daiki
AU - Tanaka, Masaru
N1 - Funding Information:
This work was supported by a Research Fellowship for Young Scientists from JSPS Grant Number JP20J12038 to T.U. This work was partly supported by Japan Society for the Promotion of Science KAKENHI Grant Number JP19H05720 to M.T. and Asahi Glass Foundation, and performed under the Cooperative Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials.”
Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2021
Y1 - 2021
N2 - In this study, a blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), was grafted onto a gold substrate with various grafting densities (σ) (σ = 0–0.18 chains nm−2), and the amount of hydrated water and mobility of the polymer chain interacting with water molecules were quantitatively evaluated using a quartz crystal microbalance with an admittance system. The amount of hydrated water decreased with increasing σ. By contrast, the mobility of the hydrated PMEA was maximum at σ ≈ 0.12 chains nm−2, revealing that the amount of high-mobility water at σ = 0.12 was higher than that at other densities. The degree of denaturation of the adsorbed fibrinogen was evaluated based on the hydrodynamic water ratio and viscoelasticity, and was found to increase with increasing σ. The denaturation of adsorbed fibrinogen was suppressed when both the amount of hydrated water and the mobility of hydrated PMEA were high. This study demonstrates that the interfacial state of the polymer chains hydrated in water is important for blood compatibility.
AB - In this study, a blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), was grafted onto a gold substrate with various grafting densities (σ) (σ = 0–0.18 chains nm−2), and the amount of hydrated water and mobility of the polymer chain interacting with water molecules were quantitatively evaluated using a quartz crystal microbalance with an admittance system. The amount of hydrated water decreased with increasing σ. By contrast, the mobility of the hydrated PMEA was maximum at σ ≈ 0.12 chains nm−2, revealing that the amount of high-mobility water at σ = 0.12 was higher than that at other densities. The degree of denaturation of the adsorbed fibrinogen was evaluated based on the hydrodynamic water ratio and viscoelasticity, and was found to increase with increasing σ. The denaturation of adsorbed fibrinogen was suppressed when both the amount of hydrated water and the mobility of hydrated PMEA were high. This study demonstrates that the interfacial state of the polymer chains hydrated in water is important for blood compatibility.
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U2 - 10.1002/pol.20210496
DO - 10.1002/pol.20210496
M3 - Article
AN - SCOPUS:85113313774
JO - Journal of Polymer Science
JF - Journal of Polymer Science
SN - 2642-4150
ER -