Effect of argon laser photoradiation on monkey retina treated with hematoporphyrin derivative. Fluorescein angiographic and light microscopic study

Y. Ohnishi, Y. Yamana, T. Ishibashi

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Abstract

To determine the method of treating retinoblastoma by means of argon laser photoradiation and hematoporphyrin derivative (HpD), we have HpD intravenously at a dose of 2.5 or 5.0 mg per kg to monkeys, and 40 minutes, one day or 3 days after this injection, argon laser photoradiation was performed at 2.0 mm diameter with a 10-minute exposure at intensities of 40, 100 or 200 mW. As photoradiation after HpD injection of 5.0 mg per kg induced severe retinal changes, 2.5 mg per kg was thought to be the dose for clinical application. Photoradiation 3 days after the injection of HpD was found to be the best choice of timing. One hundred to 200 mW intensity of laser beam was considered to be an appropriate range. Without HpD, changes in the retinal pigment epithelium and outer segment of the visual cells of the photoradiated eyes resembled those caused by conventional photocoagulation. Characteristic findings of the photoradiated retina were obstruction of the retinal vessels, fragility of the nerve fiber layer and attenuation of the inner nuclear layer. Photoradiation at a high intensity induced retention of subretinal fluid in the nonphotoradiated area. Therefore, at the time of photoradiation, light should be delivered only to the tumor.

Original languageEnglish
Pages (from-to)160-170
Number of pages11
JournalJapanese Journal of Ophthalmology
Volume31
Issue number1
Publication statusPublished - Jan 1 1987

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Hematoporphyrin Derivative
Argon
Fluorescein
Haplorhini
Retina
Lasers
Light
Injections
Subretinal Fluid
Retinal Vessels
Retinoblastoma
Retinal Pigment Epithelium
Light Coagulation
Nerve Fibers

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

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title = "Effect of argon laser photoradiation on monkey retina treated with hematoporphyrin derivative. Fluorescein angiographic and light microscopic study",
abstract = "To determine the method of treating retinoblastoma by means of argon laser photoradiation and hematoporphyrin derivative (HpD), we have HpD intravenously at a dose of 2.5 or 5.0 mg per kg to monkeys, and 40 minutes, one day or 3 days after this injection, argon laser photoradiation was performed at 2.0 mm diameter with a 10-minute exposure at intensities of 40, 100 or 200 mW. As photoradiation after HpD injection of 5.0 mg per kg induced severe retinal changes, 2.5 mg per kg was thought to be the dose for clinical application. Photoradiation 3 days after the injection of HpD was found to be the best choice of timing. One hundred to 200 mW intensity of laser beam was considered to be an appropriate range. Without HpD, changes in the retinal pigment epithelium and outer segment of the visual cells of the photoradiated eyes resembled those caused by conventional photocoagulation. Characteristic findings of the photoradiated retina were obstruction of the retinal vessels, fragility of the nerve fiber layer and attenuation of the inner nuclear layer. Photoradiation at a high intensity induced retention of subretinal fluid in the nonphotoradiated area. Therefore, at the time of photoradiation, light should be delivered only to the tumor.",
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AU - Ishibashi, T.

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