Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation

M. Mori, T. Kuwano, T. Kamori, Y. Isozaki, T. Nishihara, N. Yamauchi, M. A. Hattori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The ATP-binding cassette subfamily B member 1 (ABCB1) is an efflux transporter that excretes xenobiotics and waste matter. High expression of ABCB1 induced by forskolin (FSK) and rifampicin (RIF) in the bovine blastocysts reportedly improves the cellular quality. In the present study, interferon-α, similar to FSK and RIF, was highly potent in inducing the expression of ABCB1 in the bovine blastocysts but did not exhibit an additive effect with FSK and RIF. Bovine blastocysts stimulated by the combined treatment with FSK, RIF, and interferon-α to express high levels of ABCB1 displayed better freezing resistance as indicated by higher cell numbers in post thawing cultures. On transfer to recipients, such embryos established pregnancies with significantly higher frequencies in repeat breeder cows rather than normal ones.

Original languageEnglish
Pages (from-to)683-688
Number of pages6
JournalTheriogenology
Volume81
Issue number5
DOIs
Publication statusPublished - Mar 15 2014

All Science Journal Classification (ASJC) codes

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

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