Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain

Tatsuo Nakahara, Toshihide Kuroki, Kijiro Hashimoto, Hisao Hondo, Tetsuyuki Tsutsumi, Keisuke Motomura, Hiroshi Ueki, Makoto Hirano, Hideyuki Uchimura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effect of atypical antipsychotics on the immediate-early gene, are (activity-regulated cytoskeleton-associated gene), expression was investigated in phencyclidine (PCP)-treated rats using RT-PCR. Administration of PCP (10 mg/kg) increased arc mRNA levels in the prefrontal cortex, nucleus accumbens and posterior cingulate cortex. Pretreatment with clozapine (20 mg/kg), olanzapine (10 mg/kg) and risperidone (2 mg/kg), but not haloperidol (2 mg/kg), prevented PCP-induced arc expression in the prefrontal cortex and nucleus accumbens. Pretreatment of haloperidol increased the striatal arc mRNA levels. Clozapine, olanzapine and haloperidol inhibited the PCP-induced arc expression in the posterior cingulate cortex. These results suggest that the effects of antipsychotic drugs on PCP-induced arc expression in the prefrontal cortex and nucleus accumbens are useful for distinguishing atypical antipsychotic properties of the drugs. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)551-555
Number of pages5
JournalNeuroReport
Volume11
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

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olanzapine
Phencyclidine
Nucleus Accumbens
Haloperidol
Prefrontal Cortex
Antipsychotic Agents
Clozapine
Gyrus Cinguli
Brain
Corpus Striatum
Messenger RNA
Immediate-Early Genes
Risperidone
Cytoskeleton
Gene Expression
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nakahara, T., Kuroki, T., Hashimoto, K., Hondo, H., Tsutsumi, T., Motomura, K., ... Uchimura, H. (2000). Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain. NeuroReport, 11(3), 551-555. https://doi.org/10.1097/00001756-200002280-00025

Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain. / Nakahara, Tatsuo; Kuroki, Toshihide; Hashimoto, Kijiro; Hondo, Hisao; Tsutsumi, Tetsuyuki; Motomura, Keisuke; Ueki, Hiroshi; Hirano, Makoto; Uchimura, Hideyuki.

In: NeuroReport, Vol. 11, No. 3, 01.01.2000, p. 551-555.

Research output: Contribution to journalArticle

Nakahara, T, Kuroki, T, Hashimoto, K, Hondo, H, Tsutsumi, T, Motomura, K, Ueki, H, Hirano, M & Uchimura, H 2000, 'Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain', NeuroReport, vol. 11, no. 3, pp. 551-555. https://doi.org/10.1097/00001756-200002280-00025
Nakahara, Tatsuo ; Kuroki, Toshihide ; Hashimoto, Kijiro ; Hondo, Hisao ; Tsutsumi, Tetsuyuki ; Motomura, Keisuke ; Ueki, Hiroshi ; Hirano, Makoto ; Uchimura, Hideyuki. / Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain. In: NeuroReport. 2000 ; Vol. 11, No. 3. pp. 551-555.
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