Effect of bitter substances on a model membrane system of taste reception

Satoru Iiyama, Kiyoshi Toko, Kaoru Yamafuji

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The effect of bitter substances on the self-sustained electric oscillation of a DOPH (dioleyl phosphate)-Millipore membrane was investigated as a model system of taste reception. Caffeine and theobromine, having higher taste thresholds, had slight effect, but quinine, strychnine and nicotine, exhibiting strong bitterness, increased the frequency of the oscillation. The mode of action of bitter substances on the DOPH-Millipore membrane in the non-oscillatory state suggested that they cause the receptor potential by a change in the phase boundary potential. The intensity of action on the electric potential was associated with the threshold values of bitterness.

Original languageEnglish
Pages (from-to)2709-2714
Number of pages6
JournalAgricultural and Biological Chemistry
Volume50
Issue number11
DOIs
Publication statusPublished - Jan 1 1986

Fingerprint

bitterness
oscillation
Taste Threshold
Theobromine
phosphates
strychnine
taste sensitivity
theobromine
Membranes
Strychnine
quinine
Quinine
nicotine
Phase boundaries
phase transition
caffeine
Caffeine
Nicotine
mechanism of action
receptors

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Effect of bitter substances on a model membrane system of taste reception. / Iiyama, Satoru; Toko, Kiyoshi; Yamafuji, Kaoru.

In: Agricultural and Biological Chemistry, Vol. 50, No. 11, 01.01.1986, p. 2709-2714.

Research output: Contribution to journalArticle

Iiyama, Satoru ; Toko, Kiyoshi ; Yamafuji, Kaoru. / Effect of bitter substances on a model membrane system of taste reception. In: Agricultural and Biological Chemistry. 1986 ; Vol. 50, No. 11. pp. 2709-2714.
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