Effect of cationic comb-type copolymer on the B-Z transition of poly(dG-dC).poly(dG-dC).

Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

Research output: Contribution to journalArticle

Abstract

The structural transition of a double helical DNA from B-DNA to Z-DNA, B-Z transition, has been received growing attention because of its potential roles in biological systems and its applicability to nanobiotechnology. It was known that the B-Z transition is induced by cationic molecules. However, there are only a few reports describing cationic polymers as potential B-Z inducers. In this study, we demonstrated that cationic comb-type copolymer, poly(L-lysine)-graft-dextran, induced the B-Z transition in which distinct intermediate formation was involved. Furthermore, we suggested that the grafted-dextran plays an important role in the B-Z transition.

Original languageEnglish
Pages (from-to)113-114
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - Dec 1 2008

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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