Even though their contents in the brain are high, the function of brain carnosine and its constituents has not been clarified. Both carnosine and anserine inhibited food intake in a dose dependent fashion when injected intracerebroventricularly. The constituents of carnosine, β-alanine (β-Ala) and L-histidine (His), also inhibited food intake, but their effects were weaker than carnosine itself. Co-administration with β-Ala and His inhibited food intake similar to carnosine, but also altered other behaviors. Injection of carnosine induced hyperactivity and increased plasma corticosterone level, whereas β-Ala plus His induced hypoactivity manifested as sleep-like behavior. This later effect seemed to be derived from β-Ala, not His. These results suggest that central carnosine may act in the brain of chicks to regulate brain function and/or behavior in a manner different from its constituents.
|Number of pages||8|
|Journal||Brain Research Bulletin|
|Publication status||Published - Mar 1 2004|
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