TY - JOUR
T1 - Effect of central administration of prolactin-releasing peptide on feeding in chicks
AU - Tachibana, Tetsuya
AU - Saito, Shin
AU - Tomonaga, Shozo
AU - Takagi, Tomo
AU - Saito, Ei Suke
AU - Nakanishi, Tomonori
AU - Koutoku, Tomoyuki
AU - Tsukada, Akira
AU - Ohkubo, Takeshi
AU - Boswell, Tim
AU - Furuse, Mitsuhiro
PY - 2004/2
Y1 - 2004/2
N2 - Prolactin-releasing peptide (PrRP) is one of the inhibitory factors in feeding regulation of mammals. However, no information is available for avian species. The present study was done to clarify the effect of intracerebroventricular (ICV) injection of PrRP on feeding in chicks. Firstly, we found that ICV injection of PrRP (94-1500 pmol) significantly increased food intake in chicks. The result was completely different from those obtained in mammals. The orexigenic effect of PrRP was significantly weaker than that of neuropeptide Y (NPY), a potent orexigenic peptide, on an equimolar basis. The orexigenic effect of NPY was further enhanced with coinjection of PrRP. These results suggest the existence of a novel orexigenic mechanism in the chick brain, which might differ from NPY-involved feeding regulatory pathway. In addition, ICV injection of PrRP significantly decreased the rectal temperature, but the effect was weaker than that of NPY, suggesting that PrRP may inhibit energy expenditure in chicks. Taken together, we showed here that PrRP may be involved in the regulation of both feeding behavior and energy metabolism in the chick brain.
AB - Prolactin-releasing peptide (PrRP) is one of the inhibitory factors in feeding regulation of mammals. However, no information is available for avian species. The present study was done to clarify the effect of intracerebroventricular (ICV) injection of PrRP on feeding in chicks. Firstly, we found that ICV injection of PrRP (94-1500 pmol) significantly increased food intake in chicks. The result was completely different from those obtained in mammals. The orexigenic effect of PrRP was significantly weaker than that of neuropeptide Y (NPY), a potent orexigenic peptide, on an equimolar basis. The orexigenic effect of NPY was further enhanced with coinjection of PrRP. These results suggest the existence of a novel orexigenic mechanism in the chick brain, which might differ from NPY-involved feeding regulatory pathway. In addition, ICV injection of PrRP significantly decreased the rectal temperature, but the effect was weaker than that of NPY, suggesting that PrRP may inhibit energy expenditure in chicks. Taken together, we showed here that PrRP may be involved in the regulation of both feeding behavior and energy metabolism in the chick brain.
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U2 - 10.1016/j.physbeh.2003.12.005
DO - 10.1016/j.physbeh.2003.12.005
M3 - Article
C2 - 14984806
AN - SCOPUS:10744230492
SN - 0031-9384
VL - 80
SP - 713
EP - 719
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 5
ER -