Effect of Cepharanthin to prevent radiation induced xerostomia in head and neck cancer

Hajime Imada, Satoshi Nomoto, Takayuki Ohguri, Katsuya Yahara, Fumio Kato, Tomoaki Morioka, Yukunori Korogi

Research output: Contribution to journalArticle

Abstract

We retrospectively examined the effect of Cepharanthin to prevent radiation xerostomia in 37 cases of head and neck cancer. In the Cepharanthin group, the degree of xerostomia was milder than in the non-Cepharanthin group in spite of higher normal tissue complication probability (NTCP) and mean dose (MD) of parotid glands. In the non-Cepharanthin group, the degree of xerostomia was significantly correlated with NTCP and MD of parotid glands. MD of parotid glands and use of Cepharanthin were significantly related to more severe xerostomia by multivariate analysis with logistic regression. Cepharanthin may prevent radiation xerostomia after radiotherapy for head and neck cancer.

Original languageEnglish
Pages (from-to)1041-1045
Number of pages5
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume31
Issue number7
Publication statusPublished - Jan 1 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Imada, H., Nomoto, S., Ohguri, T., Yahara, K., Kato, F., Morioka, T., & Korogi, Y. (2004). Effect of Cepharanthin to prevent radiation induced xerostomia in head and neck cancer. Gan to kagaku ryoho. Cancer & chemotherapy, 31(7), 1041-1045.