Effect of chronic inhibition of angiotensin converting enzyme on baroreceptor reflex in essential hypertension

H. Muratani, Y. Kimura, K. Matsumura, Y. Noda, T. Eto, K. Fukiyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We examined baroreflex function and plasma angiotensin II (Ang II) before and after the treatment with an angiotensin converting enzyme inhibitor (ACEI) in eight inpatients with essential hypertension (EHT). Baroreflex sensitivity (BS), expressed as a slope of linear relationship between %changes in mean blood pressure (BP) and those in plasma concentration of norepinephrine (pNE), was greater during BP reduction by sodium nitroprusside (SNP) than during BP elevation by phenylephrine (PE). Enalapril treatment for 7 days reduced BP without a significant change in heart rate and pNE. It also increased the BS in two cases during SNP infusion and in four cases during PE infusion. Ang II was not significantly reduced after enalapril, while plasma ACE activity was suppressed by about 80 % and plasma renin activity (PRA) was elevated. The changes in BS did not correlate with the changes in Ang II. The shift of barofunction curve with an enhancement of BS by enalapril therapy might not be attributed solely to the interaction between circulating Ang II and central baroreflex mechanisms.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalClinical and Experimental Hypertension
VolumeA10
Issue numberS1
DOIs
Publication statusPublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

Fingerprint Dive into the research topics of 'Effect of chronic inhibition of angiotensin converting enzyme on baroreceptor reflex in essential hypertension'. Together they form a unique fingerprint.

  • Cite this