Effect of chrysanthemum flower extract on immunoglobulin and cytokine production by mouse spleen lymphocytes

Fumika Aramaki, Satomi Kobayashi, Ayana Oishi, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To clarify immunoregulatory activity of a chrysanthemum flower extract, the effect on immunoglobulin or cytokine production in mouse spleen lymphocytes was examined. When the lymphocytes were cultured with the extract, the IgA, IgG and IgM production was suppressed in the presence of the extract diluted with phosphate buffered saline by 9 fold. At lower concentrations, a weak stimulation of the IgM production was observed. In addition, significant suppression of IFN-γ production was observed in the 729-fold diluted extract. But was hardly detected in the 27-fold or less diluted solution. The significant suppression of IL-4 production was also observed in the 27-fold or more diluted solution during the 24 hr culture, with slight effect after the 48 hr culture. Gel filtration chromatography of the extract provided different fractions suppressing and facilitating the IFN-γ production. These results show that there were both suppression and facilitation factors of the cytokine production in the mouse spleen lymphocytes in the chrysanthemum flower extract.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume51
Issue number6
DOIs
Publication statusPublished - Jan 1 2004

All Science Journal Classification (ASJC) codes

  • Food Science

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