Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil

S. Fujii, S. Kitano, K. Ikenaka, M. Fukushima, H. Nakamura, Yoshihiko Maehara, T. Shirasaka

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Abstract

The antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on sarcoma was enhanced by oral coadministration of uracil, thymine, or thymidine. The activity was enhanced equally by thymine and by uracil but to a lesser extent by thymidine, but thymine caused loss in body weight. The antitumor activity of 5-fluorouracil (5-FU) was also enhanced by thymine or uracil, but both caused loss in body weight. Degradation of 5-FU in vitro was inhibited more by thymine than by uracil. Phosphorylation of 5-FU, however, was not inhibited by uracil, thymine, or thymidine, even at 100 times the concentration of 5-FU. These results suggest that the mechanism of enhancement of the antitumor activity of FT-207 by thymine or thymidine was similar to that by uracil, and that uracil had more effect than thymine or thymidine in enhancing antitumor effect of these drugs to FT-207 without toxicity.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalGann, The Japanese Journal of Cancer Research
Volume71
Issue number1
Publication statusPublished - Jun 27 1980

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Tegafur
Thymine
Uracil
Fluorouracil
Thymidine
Body Weight
Sarcoma
Antineoplastic Agents
Phosphorylation

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Fujii, S., Kitano, S., Ikenaka, K., Fukushima, M., Nakamura, H., Maehara, Y., & Shirasaka, T. (1980). Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. Gann, The Japanese Journal of Cancer Research, 71(1), 100-106.

Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. / Fujii, S.; Kitano, S.; Ikenaka, K.; Fukushima, M.; Nakamura, H.; Maehara, Yoshihiko; Shirasaka, T.

In: Gann, The Japanese Journal of Cancer Research, Vol. 71, No. 1, 27.06.1980, p. 100-106.

Research output: Contribution to journalArticle

Fujii, S, Kitano, S, Ikenaka, K, Fukushima, M, Nakamura, H, Maehara, Y & Shirasaka, T 1980, 'Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil', Gann, The Japanese Journal of Cancer Research, vol. 71, no. 1, pp. 100-106.
Fujii, S. ; Kitano, S. ; Ikenaka, K. ; Fukushima, M. ; Nakamura, H. ; Maehara, Yoshihiko ; Shirasaka, T. / Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. In: Gann, The Japanese Journal of Cancer Research. 1980 ; Vol. 71, No. 1. pp. 100-106.
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