Abstract
The antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on sarcoma was enhanced by oral coadministration of uracil, thymine, or thymidine. The activity was enhanced equally by thymine and by uracil but to a lesser extent by thymidine, but thymine caused loss in body weight. The antitumor activity of 5-fluorouracil (5-FU) was also enhanced by thymine or uracil, but both caused loss in body weight. Degradation of 5-FU in vitro was inhibited more by thymine than by uracil. Phosphorylation of 5-FU, however, was not inhibited by uracil, thymine, or thymidine, even at 100 times the concentration of 5-FU. These results suggest that the mechanism of enhancement of the antitumor activity of FT-207 by thymine or thymidine was similar to that by uracil, and that uracil had more effect than thymine or thymidine in enhancing antitumor effect of these drugs to FT-207 without toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 100-106 |
| Number of pages | 7 |
| Journal | Gann, The Japanese Journal of Cancer Research |
| Volume | 71 |
| Issue number | 1 |
| Publication status | Published - Jun 27 1980 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
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Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. / Fujii, S.; Kitano, S.; Ikenaka, K.; Fukushima, M.; Nakamura, H.; Maehara, Y.; Shirasaka, T.
In: Gann, The Japanese Journal of Cancer Research, Vol. 71, No. 1, 27.06.1980, p. 100-106.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil
AU - Fujii, S.
AU - Kitano, S.
AU - Ikenaka, K.
AU - Fukushima, M.
AU - Nakamura, H.
AU - Maehara, Y.
AU - Shirasaka, T.
PY - 1980/6/27
Y1 - 1980/6/27
N2 - The antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on sarcoma was enhanced by oral coadministration of uracil, thymine, or thymidine. The activity was enhanced equally by thymine and by uracil but to a lesser extent by thymidine, but thymine caused loss in body weight. The antitumor activity of 5-fluorouracil (5-FU) was also enhanced by thymine or uracil, but both caused loss in body weight. Degradation of 5-FU in vitro was inhibited more by thymine than by uracil. Phosphorylation of 5-FU, however, was not inhibited by uracil, thymine, or thymidine, even at 100 times the concentration of 5-FU. These results suggest that the mechanism of enhancement of the antitumor activity of FT-207 by thymine or thymidine was similar to that by uracil, and that uracil had more effect than thymine or thymidine in enhancing antitumor effect of these drugs to FT-207 without toxicity.
AB - The antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on sarcoma was enhanced by oral coadministration of uracil, thymine, or thymidine. The activity was enhanced equally by thymine and by uracil but to a lesser extent by thymidine, but thymine caused loss in body weight. The antitumor activity of 5-fluorouracil (5-FU) was also enhanced by thymine or uracil, but both caused loss in body weight. Degradation of 5-FU in vitro was inhibited more by thymine than by uracil. Phosphorylation of 5-FU, however, was not inhibited by uracil, thymine, or thymidine, even at 100 times the concentration of 5-FU. These results suggest that the mechanism of enhancement of the antitumor activity of FT-207 by thymine or thymidine was similar to that by uracil, and that uracil had more effect than thymine or thymidine in enhancing antitumor effect of these drugs to FT-207 without toxicity.
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M3 - Article
C2 - 6769735
AN - SCOPUS:0018854255
VL - 71
SP - 100
EP - 106
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 1
ER -