Effect of coronary artery bypass grafting with gastroepiploic artery on gastric intramucosal pH and systemic inflammation

Ken Yamaura, kozaburo akiyoshi, K. Irita, S. Takahashi

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Abstract

Background. The purpose of this study was to investigate the effect of coronary arterial bypass grafting (CABG) with gastroepiloic artery (GEA) on gastric intramucosal pH and systemic inflammation. Methods. Design: retrospective study. Setting: University hospital. Participants: 22 patients under-went CABG. Investigations: the GEA group (n=13) received CABG with the GEA graft. The non-GEA group (n=9) received conventional CABG without the GEA graft. Measurements: gastric intramucosal pH (pHi) and carbon dioxide tension (PrCO2) were assessed by capnometric air tonometry. The difference between PrCO2 and PaCO2, PCO2-gap, was also determined. Systemic inflammatory responses were evaluated by serum interleukin-6 (IL-6) and leucocyte counts. Hemodynamics, oxygen delivery index (DO2I) and uptake index (VO2I) were monitored with catheters in the radial and pulmonary arteries (thermodilution). Results. The duration of aortic cross-clamping and cardiopulmonary bypass was similar in both groups. Both groups did not show any significant difference in gastric pHi, PCO2-gap, systemic inflammation and hemodynamics. Conclusions. Our findings suggest that CABG using the GEA graft does not disturb gastric mucosal perfusion, and that laparotomy for the GEA graft does not aggravate systemic oxygen demand-supply imbalance or systemic inflammatory responses induced by hypothermic CPB. CABG with the GEA graft does not seem to pose an additional risk and is a safe technique compared with conventional CABG with regard to pHi and systemic inflammation.

Original languageEnglish
Pages (from-to)723-729
Number of pages7
JournalJournal of Cardiovascular Surgery
Volume42
Issue number6
Publication statusPublished - Dec 27 2001

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Gastroepiploic Artery
Coronary Artery Bypass
Stomach
Arteries
Inflammation
Transplants
Hemodynamics
Oxygen
Thermodilution
Radial Artery
Manometry
Cardiopulmonary Bypass
Leukocyte Count
Constriction
Carbon Dioxide
Laparotomy
Pulmonary Artery
Interleukin-6
Catheters
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Effect of coronary artery bypass grafting with gastroepiploic artery on gastric intramucosal pH and systemic inflammation. / Yamaura, Ken; akiyoshi, kozaburo; Irita, K.; Takahashi, S.

In: Journal of Cardiovascular Surgery, Vol. 42, No. 6, 27.12.2001, p. 723-729.

Research output: Contribution to journalArticle

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