Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats

Akira Hirao, Masao Yamasaki, Hitomi Chujo, Nami Koyanagi, Hiroaki Kanouchi, Shin Yasuda, Aya Matsuo, Eri Nishida, Tatsuya Rikimaru, Eiji Tsujita, Mitsuo Shimada, Yoshihiko Maehara, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat population was heavier than the control rat population at the time of PH and 1-d after PH. Conversely. CLA fed rats' liver weight was significantly lower than control rats at 7-d after PH. This suggests that dietary CLA reduced liver weight gain after PH. Dietary CLA did not affect serum aspartate aminotransferase (AST) of alanine aminotransferase (ALT) activities. However. CLA significantly reduced serum albumin levels at l-I-d but not at 7-d after PH. 5-Bromo- and 5-iododeoxyuridine incorporation into hepatocytes 1-d post PH was lower in the CLA group. In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalJournal of Nutritional Science and Vitaminology
Volume50
Issue number1
DOIs
Publication statusPublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats'. Together they form a unique fingerprint.

  • Cite this

    Hirao, A., Yamasaki, M., Chujo, H., Koyanagi, N., Kanouchi, H., Yasuda, S., Matsuo, A., Nishida, E., Rikimaru, T., Tsujita, E., Shimada, M., Maehara, Y., Tachibana, H., & Yamada, K. (2004). Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats. Journal of Nutritional Science and Vitaminology, 50(1), 9-12. https://doi.org/10.3177/jnsv.50.9