Effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats

Jiongyan Gu, Yoko Wakizono, Aika Dohi, Michiko Nonaka, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We examined the effect of three dietary fats, safflower oil (SAF) rich in linoleic acid, borage oil (BOR) rich in γ-linolenic acid, and perilla oil (PER) rich in α-linolenic acid, on the lipid metabolism, and chemical mediator and immunoglobulin levels in Sprague-Dawley rats, as well as the dietary effect of sesame-derived antioxidative sesamin. The serum cholesterol, phospholipid, triglyceride, prostaglandin E2 level and splenic leukotriene B4 level were lower in the rats fed on BOR or PER than in those fed on SAF. SES feeding suppressed the expression of the lipid-decreasing effect of BOR, but not in the rats fed on PER. In respect of the fatty acid composition of the liver and spleen, PER feeding gave a lower arachidonic acid level, and higher eicosapentaenoic and docosahexaenoic acid levels than SAF feeding did, while the effect of BOR feeding was marginal. The effect of SES feeding on fatty acid composition was much smaller than that of dietary fats. In respect of immunoglobulin production, PER+SES feeding gave the lowest IgE productivity in the mesenteric lymph node lymphocytes. These results suggest that PER feeding regulated lipid metabolism and exerted an anti-allergic effect by a different mechanism from that with BOR feeding.

Original languageEnglish
Pages (from-to)1917-1924
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume62
Issue number10
DOIs
Publication statusPublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats'. Together they form a unique fingerprint.

Cite this