Effect of Dosing Time on Trazodone Kinetics

Shigeyuki Nakano, Nobuya Ogawa, Kouki Watanabe, Tetsuro Naruo, Nobuyuki Takaoka, Shigehiro Ohdo, Tatsuru Arai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUCo-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalRinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Volume23
Issue number2
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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