Effect of Drug-metabolizing Enzyme Activity Induced by PCB on the Residence Time of Oxolinic Acid, Piromidic Acid and Nalidixic Acid in Carp

Yuji Oshima, Liestiaty Fachrudin, Noriko Ishida, Nobuyoshi Imada, Kunio Kobayashi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A study was made of the effect of drug-metabolizing enzyme activity induced by polychlorinated biphenyl (PCB) on the residence time of quinoline antibacterial agents in carp Cyprinus carpio. Carp were fed with a diet containing PCB (1 mg PCB/kg body weight/day) for 2 weeks to induce drug-metabolizing enzymes. After pretreatment, three kinds of quinoline antibacterial agents (oxolinic acid, piromidic acid and nalidixic acid) were individually administered in feed to PCB-treated or nontreated (as control) fish as a single dose of 20 mg/kg body weight. The peak concentrations of oxolinic acid in the blood, liver and muscle of PCB-treated fish were lower than half of those in the control. The concentrations of piromidic acid in the liver, muscle and kidney of PCB-treated fish were undetectable throughout the experiment (2 to 98 h post dosing), except in the blood. However, the residence time and concentration of nalidixic acid in the tissues of PCB-treated fish showed no significant difference compared with those in the control.

Original languageEnglish
Pages (from-to)302-306
Number of pages5
JournalFisheries science
Volume62
Issue number2
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Aquatic Science

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