Effect of drug-metabolizing enzyme activity induced by PCB on the duration of drugs in fish

Y. Oshima, K. Kobayashi, J. F. Lumbanbatu, K. Ooie, Y. Kawahara, N. Imada

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A study was made of the induction of drug-metabolizing enzyme activity and the effect of the induced activity on the duration of drugs in fish. Carp were fed with a diet containing PCB ( 0.1 mg PCB 100 g body weight day-1) for 2 weeks to induce drug-metabolizing enzymes. After pretreatment, oxolinic acid, thiamphenicol and oxytetracycline were administered in feed to PCB-treated and nontreated (as control) fish as a single dose of 20, 50, and 50 mg/kg body weight, respectively. The peak concentrations of oxolinic acid in the blood, kidney, liver, and muscle of fish in the PCB group were lower than the half of those in the controls. Furthermore, the duration times of oxolinic acid in the tissues of PCB-treated fish were also shorter than those in the control. However, the duration of thiamphenicol and oxytetracycline showed no significant changes relating to PCB treatment.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
Issue number1-2
Publication statusPublished - Feb 15 1994


All Science Journal Classification (ASJC) codes

  • Aquatic Science

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