Effect of etoposide on a human pancreatic cancer cell line exposed to high dose X-ray irradiation

Kazuhiro Mizumoto, M. Tanaka, R. Aramaki

Research output: Contribution to journalArticle

Abstract

Effects of etoposide on the cell deaths of a human pancreatic cancer cell line by exposure to high-dose X-ray irradiation were examined. Both high-dose X-ray irradiation and etoposide killed the pancreatic cancer cells by apoptosis. With 30 gray irradiation, simultaneous treatment of etoposide did not alter the percentage of cell deaths; however, 24-hr prior treatment of etoposide killed a significantly larger percentage of the cells, accompanying the accumulation to the S phase of the cell cycle. The results indicate that apoptosis of human pancreatic cancer cell line induced by high dose X-ray irradiation can be enhanced by prior treatment with etoposide.

Original languageEnglish
Pages (from-to)1673-1675
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume23
Issue number12
Publication statusPublished - Dec 2 1996

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Etoposide
Pancreatic Neoplasms
X-Rays
Cell Line
Cell Death
Apoptosis
S Phase
Cell Cycle

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Effect of etoposide on a human pancreatic cancer cell line exposed to high dose X-ray irradiation. / Mizumoto, Kazuhiro; Tanaka, M.; Aramaki, R.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 23, No. 12, 02.12.1996, p. 1673-1675.

Research output: Contribution to journalArticle

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