Effect of extracellular adenosine 5'-triphosphate on principal neurons of the rat ventral tegmental area

Wolfgang Poelchen, Dirk Sieler, Kazuhide Inoue, Peter Illes

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Intracellutar recordings were made in a midbrain slice preparation of the rat brain containing the ventral tegmental area (VTA). Dopaminergic principal cells were identified by their electrophysiological properties and their hyperpolarizing responses to dopamine. Superfusion with dopamine (100 μM) caused hyperpolarization and a decrease of the apparent input resistance. By contrast, two structural analogues of ATP, 2-methylthio ATP (2-MeSATP; 10 μM) and α β-methylene ATP (α, β-meATP; 30 μM) had no effect, when added to the superfusion medium. Pressure applied dopamine also hyperpolarized the membrane, while both 2-MeSATP and α, β-meATP were ineffective. Hence, dopaminergic principal neurons of the VTA do not possess somatic P2 purinoceptors present on peripheral and central noradrenergic neurons.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalBrain Research
Volume800
Issue number1
DOIs
Publication statusPublished - Jul 27 1998
Externally publishedYes

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Ventral Tegmental Area
Dopamine
Adenosine Triphosphate
Neurons
Purinergic P2 Receptors
Adrenergic Neurons
Dopaminergic Neurons
Mesencephalon
Pressure
Membranes
Brain
2-methylthio-ATP

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Effect of extracellular adenosine 5'-triphosphate on principal neurons of the rat ventral tegmental area. / Poelchen, Wolfgang; Sieler, Dirk; Inoue, Kazuhide; Illes, Peter.

In: Brain Research, Vol. 800, No. 1, 27.07.1998, p. 170-173.

Research output: Contribution to journalArticle

Poelchen, Wolfgang ; Sieler, Dirk ; Inoue, Kazuhide ; Illes, Peter. / Effect of extracellular adenosine 5'-triphosphate on principal neurons of the rat ventral tegmental area. In: Brain Research. 1998 ; Vol. 800, No. 1. pp. 170-173.
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