Effect of functional groups at hole edges on cisplatin release from inside single-wall carbon nanohorns

Kumiko Ajima, Masako Yudasaka, Alan Maigné, Jin Miyawaki, Sumio Iijima

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We incorporated cisplatin inside single-wall carbon nanohorns (NHs) and revealed that 70% of the cisplatin was released from NHs having holes with hydrogen-terminated edges when they were immersed in phosphate-buffered saline (PBS). However, only 15% was released from NHs having holes with oxygen-containing functional groups at the hole edges (NHox). Elemental analysis indicated that -COOH and -OH groups at the hole edges of NHox changed mainly to -COONa and -ONa groups by immersion in PBS. These groups decreased the practical hole diameters, which resulted in hindering the cisplatin release from NHox. This means that the release of the material from inside NHox would be controlled by chemically modifying the functional groups attached to the hole edges of NHox; thus the potential applicability of NHox to a material carrier would be enhanced.

Original languageEnglish
Pages (from-to)5773-5778
Number of pages6
JournalJournal of Physical Chemistry B
Issue number11
Publication statusPublished - Mar 23 2006


All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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