Effect of functionally-Graded Calcium titanate film, prepared by metal-organic chemical vapor deposition, on titanium implant

Naru Shiraishi, Risa Ishiko-Uzuka, Kenta Takahashi, Toru Ogawa, Takahisa Anada, Osamu Suzuki, Takashi Goto, Keiichi Sasaki

Research output: Contribution to journalArticle

Abstract

Calcium Titanate (CaTiO3) has been introduced as an attractive biomaterial for the enhancement of calcium phosphate deposition in vivo and in vitro. We hypothesized that CaTiO3 directly coated on titanium (Ti) by metal-organic chemical vapor deposition (MOCVD) could be a suitable candidate for biocompatible coatings for medical devices, particularly dental implants. To prove this hypothesis, surface characterization, cell culture, and animal study were completed in this study. The result of this study showed that CTO 800, a CaTiO3 film prepared by heating at 800 °C, had a high hydrophilic surface. Mouse bone marrow stromal ST-2 cells cultured on substrates and CTO 800 exhibited cell differentiation, represented by alkaline phosphatase activity, compared with cells cultured on non-coated Ti and CTO 700 (a CaTiO3 film prepared by heating at 700 °C). The push-in test value of CTO 800, a parameter that indicates the degree of osseointegration, was significantly higher than that of Ti. Calcium titanate coated on Ti by MOCVD has the potential to accelerate the process of osseointegration; thus, our results support the use of CaTiO3 coating for biocompatible biomaterial for medical applications, particularly dental implants.

Original languageEnglish
Article number172
JournalApplied Sciences (Switzerland)
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 4 2019

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Organic Chemicals
Organic chemicals
Titanium
metalorganic chemical vapor deposition
calcium
Chemical vapor deposition
Calcium
titanium
Metals
Dental prostheses
cultured cells
Biomaterials
Biocompatible Materials
coatings
Heating
Coatings
phosphatases
heating
calcium phosphates
bone marrow

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

Cite this

Effect of functionally-Graded Calcium titanate film, prepared by metal-organic chemical vapor deposition, on titanium implant. / Shiraishi, Naru; Ishiko-Uzuka, Risa; Takahashi, Kenta; Ogawa, Toru; Anada, Takahisa; Suzuki, Osamu; Goto, Takashi; Sasaki, Keiichi.

In: Applied Sciences (Switzerland), Vol. 9, No. 1, 172, 04.01.2019.

Research output: Contribution to journalArticle

Shiraishi, Naru ; Ishiko-Uzuka, Risa ; Takahashi, Kenta ; Ogawa, Toru ; Anada, Takahisa ; Suzuki, Osamu ; Goto, Takashi ; Sasaki, Keiichi. / Effect of functionally-Graded Calcium titanate film, prepared by metal-organic chemical vapor deposition, on titanium implant. In: Applied Sciences (Switzerland). 2019 ; Vol. 9, No. 1.
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