The current research deals with the study on the effect of heat and mass transfer characteristics on the adsorption dehumidification system performance. The Nusselt number (Nu) and Sherwood number (Sh) was evaluated under laminar regions, with the Reynolds number (Re) ranging from 440 to 722. Each investigation was conducted with the water vapor as a working fluid, which was flow under the maintained temperatures of 20 ºC and 55 ºC during the adsorption and desorption process, respectively. Numerical predictions were developed to predict the system characteristics by considering the Nu values obtained from the experimental data. Increasing Re leads to the improvement of Nu and Sh values; however, it negatively influences the system performance. It also suggested that the properties of the interface between desiccant layers and water vapor in the predictive approaches need to be carefully acquired.