Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial

Toshimi Kaido, Masahiro Shinoda, Yukihiro Inomata, Takahito Yagi, Nobuhisa Akamatsu, Yasutsugu Takada, Hideki Ohdan, Tsuyoshi Shimamura, Yasuhiro Ogura, Susumu Eguchi, Hidetoshi Eguchi, Satoshi Ogata, Tomoharu Yoshizumi, Toshihiko Ikegami, Michio Yamamoto, Satoshi Morita, Shinji Uemoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Postoperative early oral or enteral intake is a crucial element of the Enhanced Recovery After Surgery (ERAS) protocol. However, normal food intake or enteral feeding cannot be started early in the presence of coexisting bowel dysfunction in patients undergoing liver transplantation (LT). The aim of this multicenter, randomized, double-blinded, placebo-controlled trial was to determine the enhancement effects of the Japanese herbal medicine Daikenchuto (DKT) on oral/enteral caloric intake in patients undergoing LT. Methods: A total of 112 adult patients undergoing LT at 14 Japanese centers were enrolled. The patients were randomly assigned to receive either DKT or placebo from postoperative day (POD) 1 to 14. The primary endpoints were total oral/enteral caloric intake, abdominal distension, and pain on POD 7. The secondary endpoints included sequential changes in total oral/enteral caloric intake after LT, and portal venous flow volume and velocity in the graft. Results: A total of 104 patients (DKT, n = 55; placebo, n = 49) were included in the analyses. There were no significant differences between the two groups in terms of primary endpoints. However, postoperative total oral/enteral caloric intake was significantly accelerated in the DKT group compared with the placebo group (P = 0.023). Moreover, portal venous flow volume (POD 10, 14) and velocity (POD 14) were significantly higher in the DKT group than in the placebo group (P = 0.047, P = 0.025, P = 0.014, respectively). Conclusions: Postoperative administration of DKT may enhance total oral/enteral caloric intake and portal venous flow volume and velocity after LT and favorably contribute to the performance of the ERAS protocol.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalNutrition
Volume54
DOIs
Publication statusPublished - Oct 2018

Fingerprint

Herbal Medicine
Energy Intake
Liver Transplantation
Small Intestine
Randomized Controlled Trials
Placebos
Enteral Nutrition
Abdominal Pain
dai-kenchu-to
Eating
Transplants

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation : A multicenter, randomized controlled trial. / Kaido, Toshimi; Shinoda, Masahiro; Inomata, Yukihiro; Yagi, Takahito; Akamatsu, Nobuhisa; Takada, Yasutsugu; Ohdan, Hideki; Shimamura, Tsuyoshi; Ogura, Yasuhiro; Eguchi, Susumu; Eguchi, Hidetoshi; Ogata, Satoshi; Yoshizumi, Tomoharu; Ikegami, Toshihiko; Yamamoto, Michio; Morita, Satoshi; Uemoto, Shinji.

In: Nutrition, Vol. 54, 10.2018, p. 68-75.

Research output: Contribution to journalArticle

Kaido, T, Shinoda, M, Inomata, Y, Yagi, T, Akamatsu, N, Takada, Y, Ohdan, H, Shimamura, T, Ogura, Y, Eguchi, S, Eguchi, H, Ogata, S, Yoshizumi, T, Ikegami, T, Yamamoto, M, Morita, S & Uemoto, S 2018, 'Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial', Nutrition, vol. 54, pp. 68-75. https://doi.org/10.1016/j.nut.2018.02.022
Kaido, Toshimi ; Shinoda, Masahiro ; Inomata, Yukihiro ; Yagi, Takahito ; Akamatsu, Nobuhisa ; Takada, Yasutsugu ; Ohdan, Hideki ; Shimamura, Tsuyoshi ; Ogura, Yasuhiro ; Eguchi, Susumu ; Eguchi, Hidetoshi ; Ogata, Satoshi ; Yoshizumi, Tomoharu ; Ikegami, Toshihiko ; Yamamoto, Michio ; Morita, Satoshi ; Uemoto, Shinji. / Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation : A multicenter, randomized controlled trial. In: Nutrition. 2018 ; Vol. 54. pp. 68-75.
@article{8104a28012b0463593ce3378ba0038d0,
title = "Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial",
abstract = "Objective: Postoperative early oral or enteral intake is a crucial element of the Enhanced Recovery After Surgery (ERAS) protocol. However, normal food intake or enteral feeding cannot be started early in the presence of coexisting bowel dysfunction in patients undergoing liver transplantation (LT). The aim of this multicenter, randomized, double-blinded, placebo-controlled trial was to determine the enhancement effects of the Japanese herbal medicine Daikenchuto (DKT) on oral/enteral caloric intake in patients undergoing LT. Methods: A total of 112 adult patients undergoing LT at 14 Japanese centers were enrolled. The patients were randomly assigned to receive either DKT or placebo from postoperative day (POD) 1 to 14. The primary endpoints were total oral/enteral caloric intake, abdominal distension, and pain on POD 7. The secondary endpoints included sequential changes in total oral/enteral caloric intake after LT, and portal venous flow volume and velocity in the graft. Results: A total of 104 patients (DKT, n = 55; placebo, n = 49) were included in the analyses. There were no significant differences between the two groups in terms of primary endpoints. However, postoperative total oral/enteral caloric intake was significantly accelerated in the DKT group compared with the placebo group (P = 0.023). Moreover, portal venous flow volume (POD 10, 14) and velocity (POD 14) were significantly higher in the DKT group than in the placebo group (P = 0.047, P = 0.025, P = 0.014, respectively). Conclusions: Postoperative administration of DKT may enhance total oral/enteral caloric intake and portal venous flow volume and velocity after LT and favorably contribute to the performance of the ERAS protocol.",
author = "Toshimi Kaido and Masahiro Shinoda and Yukihiro Inomata and Takahito Yagi and Nobuhisa Akamatsu and Yasutsugu Takada and Hideki Ohdan and Tsuyoshi Shimamura and Yasuhiro Ogura and Susumu Eguchi and Hidetoshi Eguchi and Satoshi Ogata and Tomoharu Yoshizumi and Toshihiko Ikegami and Michio Yamamoto and Satoshi Morita and Shinji Uemoto",
year = "2018",
month = "10",
doi = "10.1016/j.nut.2018.02.022",
language = "English",
volume = "54",
pages = "68--75",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation

T2 - A multicenter, randomized controlled trial

AU - Kaido, Toshimi

AU - Shinoda, Masahiro

AU - Inomata, Yukihiro

AU - Yagi, Takahito

AU - Akamatsu, Nobuhisa

AU - Takada, Yasutsugu

AU - Ohdan, Hideki

AU - Shimamura, Tsuyoshi

AU - Ogura, Yasuhiro

AU - Eguchi, Susumu

AU - Eguchi, Hidetoshi

AU - Ogata, Satoshi

AU - Yoshizumi, Tomoharu

AU - Ikegami, Toshihiko

AU - Yamamoto, Michio

AU - Morita, Satoshi

AU - Uemoto, Shinji

PY - 2018/10

Y1 - 2018/10

N2 - Objective: Postoperative early oral or enteral intake is a crucial element of the Enhanced Recovery After Surgery (ERAS) protocol. However, normal food intake or enteral feeding cannot be started early in the presence of coexisting bowel dysfunction in patients undergoing liver transplantation (LT). The aim of this multicenter, randomized, double-blinded, placebo-controlled trial was to determine the enhancement effects of the Japanese herbal medicine Daikenchuto (DKT) on oral/enteral caloric intake in patients undergoing LT. Methods: A total of 112 adult patients undergoing LT at 14 Japanese centers were enrolled. The patients were randomly assigned to receive either DKT or placebo from postoperative day (POD) 1 to 14. The primary endpoints were total oral/enteral caloric intake, abdominal distension, and pain on POD 7. The secondary endpoints included sequential changes in total oral/enteral caloric intake after LT, and portal venous flow volume and velocity in the graft. Results: A total of 104 patients (DKT, n = 55; placebo, n = 49) were included in the analyses. There were no significant differences between the two groups in terms of primary endpoints. However, postoperative total oral/enteral caloric intake was significantly accelerated in the DKT group compared with the placebo group (P = 0.023). Moreover, portal venous flow volume (POD 10, 14) and velocity (POD 14) were significantly higher in the DKT group than in the placebo group (P = 0.047, P = 0.025, P = 0.014, respectively). Conclusions: Postoperative administration of DKT may enhance total oral/enteral caloric intake and portal venous flow volume and velocity after LT and favorably contribute to the performance of the ERAS protocol.

AB - Objective: Postoperative early oral or enteral intake is a crucial element of the Enhanced Recovery After Surgery (ERAS) protocol. However, normal food intake or enteral feeding cannot be started early in the presence of coexisting bowel dysfunction in patients undergoing liver transplantation (LT). The aim of this multicenter, randomized, double-blinded, placebo-controlled trial was to determine the enhancement effects of the Japanese herbal medicine Daikenchuto (DKT) on oral/enteral caloric intake in patients undergoing LT. Methods: A total of 112 adult patients undergoing LT at 14 Japanese centers were enrolled. The patients were randomly assigned to receive either DKT or placebo from postoperative day (POD) 1 to 14. The primary endpoints were total oral/enteral caloric intake, abdominal distension, and pain on POD 7. The secondary endpoints included sequential changes in total oral/enteral caloric intake after LT, and portal venous flow volume and velocity in the graft. Results: A total of 104 patients (DKT, n = 55; placebo, n = 49) were included in the analyses. There were no significant differences between the two groups in terms of primary endpoints. However, postoperative total oral/enteral caloric intake was significantly accelerated in the DKT group compared with the placebo group (P = 0.023). Moreover, portal venous flow volume (POD 10, 14) and velocity (POD 14) were significantly higher in the DKT group than in the placebo group (P = 0.047, P = 0.025, P = 0.014, respectively). Conclusions: Postoperative administration of DKT may enhance total oral/enteral caloric intake and portal venous flow volume and velocity after LT and favorably contribute to the performance of the ERAS protocol.

UR - http://www.scopus.com/inward/record.url?scp=85046706856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046706856&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2018.02.022

DO - 10.1016/j.nut.2018.02.022

M3 - Article

AN - SCOPUS:85046706856

VL - 54

SP - 68

EP - 75

JO - Nutrition

JF - Nutrition

SN - 0899-9007

ER -