Effect of highly active antiretroviral therapy (HAART) on hypergammaglobulinemia in HIV infected patients

Yong Jeong, H. Ikematsu, M. Yamamoto, K. Chijiwa, I. Ariyama, W. Li, J. Hayashi, T. Shirai, S. Kashiwagi

Research output: Contribution to journalArticle

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Abstract

To investigate the mechanism of hypergammaglobulinemia in HIV infected patients, the effect of highly active antiretroviral therapy (HAART) on the hypergammaglobulinemia was analyzed. Involved in this study were 34 untreated, 21 HAART-effective (complete response) and 14 HAART-non-effective (partial response) patients. Serum levels of HIV-RNA and gammaglobulin and immunoglobulin (Ig) isotypes were measured. Mean HIV-RNA levels of untreated and partial response patients were 1.6 x 10(4) copies/ml and 0.4 x 10(4) copies/ml, respectively. HIV-RNA levels of all complete response patients were below 4.0 x 10(2) copies/ml. Mean gammaglobulin percentages of untreated, partial response and complete response patients were 24.4%, 21.8% and 17.9%, respectively (p < 0.01 in untreated vs complete response patients). Mean IgG levels in the three groups were 2,489 mg/dl, 1,947 mg/dl and 1,618 mg/dl, respectively (p < 0.001 in untreated vs complete response patients). IgA levels were high in some untreated patients and lower in complete response patients. IgE levels were increased in some untreated and partial response patients, but there was no significant difference among the three groups. These results suggested that the hypergammaglobulinemia found in HIV infected patients was associated with HIV replication. The activation mechanism might differ by Ig isotypes.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume75
Issue number7
DOIs
Publication statusPublished - Jan 1 2001

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Hypergammaglobulinemia
Highly Active Antiretroviral Therapy
HIV
Immunoglobulin Isotypes
RNA
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Effect of highly active antiretroviral therapy (HAART) on hypergammaglobulinemia in HIV infected patients. / Jeong, Yong; Ikematsu, H.; Yamamoto, M.; Chijiwa, K.; Ariyama, I.; Li, W.; Hayashi, J.; Shirai, T.; Kashiwagi, S.

In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 75, No. 7, 01.01.2001, p. 535-540.

Research output: Contribution to journalArticle

Jeong, Yong ; Ikematsu, H. ; Yamamoto, M. ; Chijiwa, K. ; Ariyama, I. ; Li, W. ; Hayashi, J. ; Shirai, T. ; Kashiwagi, S. / Effect of highly active antiretroviral therapy (HAART) on hypergammaglobulinemia in HIV infected patients. In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 2001 ; Vol. 75, No. 7. pp. 535-540.
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