Effect of intracerebroventricular injection of l-pipecolic acid on gab a concentrations in brain sites of neonatal chicks

T. Takagi, Y. H. Choi, T. Tachibana, D. M. Denbow, M. Furuse

Research output: Contribution to journalArticle

Abstract

L-pipecolic acid (L-PA) is a major metabolic intermediate of L-lysine in the mammalian and chicken brain, which enhances y-amino butyric acid (GABA) release and inhibits GABA re-uptake. Our previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks. These behaviors which are associated with the GABA system, suggest a link between L-PA and GABA. The present study was designed to determine GABA concentrations in several chick brain sites after i.c.v. injection of L-PA. Unexpectedly, L-PA tended to decrease GABA concentrations in all brain sites tested except for the pons-medulla oblongata and the decrease was largest in the optic lobe. These results, taken together with previous findings, support a link between i.c.v. L-PA and extracellular GABA concentrations.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalJournal of Applied Animal Research
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

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