TY - JOUR
T1 - Effect of intravenous administration of glucagon-like peptide 1 on growth hormone secretion in sheep
AU - Kurose, Y.
AU - Kuwahara, A.
AU - Oshiba, Y.
AU - Takahashi, H.
AU - Watanabe, Y.
AU - Terashima, Y.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - We examined effects of intravenous administration of glucagon-like peptide 1 (GLP-1) on growth hormone (GH) secretion in ruminants. Four Suffolk rams, aged 2 years, were fed at 16.00 h. They were bled every 5 min from 12.00 until 17.00 h. GLP-1(7-36)amide was intravenously infused at a rate of 1.2 pmol/kg/min from 12.00 to 17.00 h. GH peak frequency was significantly (P<0.05) increased. GLP-1 did not affect GH peak amplitude. Plasma insulin levels transiently increased just after the start of GLP-1 infusion. Plasma glucose levels did not change. GLP-1 may be a physiological regulator of spontaneous pulsatile GH secretion in ruminants.
AB - We examined effects of intravenous administration of glucagon-like peptide 1 (GLP-1) on growth hormone (GH) secretion in ruminants. Four Suffolk rams, aged 2 years, were fed at 16.00 h. They were bled every 5 min from 12.00 until 17.00 h. GLP-1(7-36)amide was intravenously infused at a rate of 1.2 pmol/kg/min from 12.00 to 17.00 h. GH peak frequency was significantly (P<0.05) increased. GLP-1 did not affect GH peak amplitude. Plasma insulin levels transiently increased just after the start of GLP-1 infusion. Plasma glucose levels did not change. GLP-1 may be a physiological regulator of spontaneous pulsatile GH secretion in ruminants.
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U2 - 10.22358/jafs/73958/2004
DO - 10.22358/jafs/73958/2004
M3 - Article
AN - SCOPUS:6944237477
SN - 1230-1388
VL - 13
SP - 433
EP - 435
JO - Journal of Animal and Feed Sciences
JF - Journal of Animal and Feed Sciences
IS - SUPPL. 1
ER -